{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:24:05Z","timestamp":1788564245577,"version":"build-2803163510"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,10,28]],"date-time":"2010-10-28T00:00:00Z","timestamp":1288224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,10,28]],"date-time":"2010-10-28T00:00:00Z","timestamp":1288224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Background:<\/i> The knowledge about the natural history of stroke in Chagas disease is incomplete. <i>Methods:<\/i> Vascular risk factors and stroke subtypes of asymptomatic <i> Trypanosoma cruzi<\/i>-infected patients with no clinical evidence of heart failure were assessed. They were compared with chronic chagasic cardiomyopathy patients who suffered a stroke and with a control group of 60 <i>T. cruzi<\/i>-noninfected stroke patients. Eighty-six consecutive chagasic stroke patients (mean age: 57.4 years; 64% females) were studied. <i>Results:<\/i> 38.4% of chagasic stroke patients had asymptomatic <i>T. cruzi<\/i> infection. Smoking was more frequent in asymptomatic chagasic stroke patients (21.2 vs. 5.7%; p = 0.04). Prevalence of hypertension, diabetes and prior stroke was similar in both groups. Small-vessel infarction (15.6 vs. 3.8%) and large-vessel atherosclerosis (9.4 vs. 3.8%) were significantly more frequent in asymptomatic than in symptomatic <i>T. cruzi-<\/i>infected stroke patients (p = 0.001). Nevertheless, their frequency was even higher in <i>T. cruzi<\/i>-noninfected stroke patients (36.7 and 13.3%, respectively). Apical aneurysm (27.3%), left atrial dilatation (12.1%), left ventricle hypokinesia (9.4%) and right bundle branch block (36.4%) were also detected in asymptomatic <i>T. cruzi<\/i>-infected stroke patients. <i>Conclusions:<\/i> Ischemic stroke may be the first manifestation of Chagas disease in asymptomatic patients with mild left ventricle dysfunction. Other noncardioembolic stroke subtypes can occur in asymptomatic <i>T. cruzi<\/i>-infected patients.<\/jats:p>","DOI":"10.1159\/000320248","type":"journal-article","created":{"date-parts":[[2010,10,28]],"date-time":"2010-10-28T07:38:53Z","timestamp":1288251533000},"page":"24-28","source":"Crossref","is-referenced-by-count":46,"title":["Stroke in Asymptomatic <i>Trypanosoma cruzi<\/i>-Infected Patients"],"prefix":"10.1159","volume":"31","author":[{"given":"Francisco Javier","family":"Carod-Artal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Pedro","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago","family":"Falcao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,10,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.trstmh.2007.06.007"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1086%2F605091"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.actatropica.2009.02.005"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ahj.2008.08.024"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jns.2007.05.022"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2810%2970042-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.74.4.516"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000163104.92943.50"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161%2FSTROKEAHA.109.560854"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000210433"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS1473-3099%2801%2900065-2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.106.624296"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000177866.13451.e4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000182819"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136%2Fhrt.2008.159624"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2143%2FAC.55.1.2005715"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jns.2008.12.015"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320248","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:49:20Z","timestamp":1745437760000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000320248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,28]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,12,1]]},"published-print":{"date-parts":[[2010,12,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000320248","archive":["Portico"],"relation":{},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"value":"1015-9770","type":"print"},{"value":"1421-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,28]]}}}