{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:36:04Z","timestamp":1778837764443,"version":"3.51.4"},"reference-count":32,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; \u03b2&lt;sup&gt;S&lt;\/sup&gt;-Haplotype prevalence and its associations with clinical and hematological characteristics were assessed in Brazilian children with sickle cell anemia or S\u03b2&amp;#8304;-thalassemia. &lt;i&gt;Methods:&lt;\/i&gt; A retrospective randomized cohort study was undertaken with 208 SS and 13 S\u03b2&amp;#8304;-thalassemia children derived from the Newborn Screening Program of the state of Minas Gerais. \u03b2&lt;sup&gt;S&lt;\/sup&gt;-Haplotypes were determined by PCR-RFLP. &lt;i&gt;Results:&lt;\/i&gt; Thirty-nine percent of the SS subjects had the CAR\/CAR genotype, 33% had CAR\/Ben, 24% had Ben\/Ben, 1% had CAR\/Atp, 1% had Ben\/Atp, and 1% had Arab-Indian\/Ben; 1% could not be characterized. Of the S\u03b2&amp;#8304;-thalassemia children, 5 were CAR\/undefined, 2 were Ben\/undefined, and 1 was CAM\/undefined. There was no significant association between \u03b2&lt;sup&gt;S&lt;\/sup&gt;-haplotypes and the total Hb, Hb F, MCV, MCH, WBC, and reticulocyte count among the SS children. Likewise, no significant association was detected between \u03b2&lt;sup&gt;S&lt;\/sup&gt;-haplotypes and the frequency of acute chest syndrome episodes, blood transfusions, splenic sequestration, or cerebrovascular disease (high-risk\/conditional transcranial Doppler ultrasonography or clinical stroke). A limited number of S\u03b2&amp;#8304;-thalassemia children precluded valid analyses. &lt;i&gt;Conclusions:&lt;\/i&gt; The prevalence of \u03b2&lt;sup&gt;S&lt;\/sup&gt;-haplotypes in this study is in agreement with the historical records of African slaves brought to the state of Minas Gerais. Furthermore, \u03b2&lt;sup&gt;S&lt;\/sup&gt;-haplotypes CAR and Ben were not associated with any analyzed feature of children with sickle cell anemia.<\/jats:p>","DOI":"10.1159\/000320271","type":"journal-article","created":{"date-parts":[[2010,10,13]],"date-time":"2010-10-13T10:35:18Z","timestamp":1286966118000},"page":"162-170","source":"Crossref","is-referenced-by-count":34,"title":["\u03b2-Globin Gene Cluster Haplotypes in a Cohort of 221 Children with Sickle Cell Anemia or S\u03b2&amp;#8304;-Thalassemia and Their Association with Clinical and Hematological Features"],"prefix":"10.1159","volume":"124","author":[{"given":"Andr\u00e9 Rolim","family":"Belis\u00e1rio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Lobato","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Mercy 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