{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:53:41Z","timestamp":1778864021523,"version":"3.51.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To investigate the prevalence of haptoglobin (Hp) gene alleles in Kuwaiti sickle cell disease (SCD) patients, who generally have a mild phenotype, and compare the pattern to Nigerian SCD patients whose SCD phenotype is more severe. &lt;i&gt;Subjects and Methods:&lt;\/i&gt; Hp genotyping was carried out in a group of 82 and 54 SCD patients from Kuwait and Nigeria, respectively, and appropriate Hb AA controls. The Hp genotyping was done using a PCR technique followed by agarose gel electrophoresis. &lt;i&gt;Results:&lt;\/i&gt; The frequency of the Hp-2 allele was 73.8% among Kuwaiti SCD patients, while the Hp-1 allele predominated among Nigerian patients (60.7%). However, the differences were not significant (p &gt; 0.05) when the allele distributions were compared between Kuwaiti SCD and their AA counterparts or between Nigerian SCD and their AA controls. There was no association of Hp-2 allele with frequent vaso-occlusive crisis among the Kuwaiti SCD patients. &lt;i&gt;Conclusion:&lt;\/i&gt; The distribution of Hp alleles appears to follow ethnic and geographical trends. Their role in the pathophysiology of pain crisis is not clear.<\/jats:p>","DOI":"10.1159\/000320302","type":"journal-article","created":{"date-parts":[[2010,9,29]],"date-time":"2010-09-29T06:43:56Z","timestamp":1285742636000},"page":"447-450","source":"Crossref","is-referenced-by-count":21,"title":["Haptoglobin Gene Polymorphisms in Sickle Cell Disease Patients with Different \u03b2&lt;sup&gt;S&lt;\/sup&gt;-Globin Gene Haplotypes"],"prefix":"10.1159","volume":"19","author":[{"given":"A.D.","family":"Adekile","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.Z.","family":"Haider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,9,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.2000.tb06201.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.blre.2006.07.001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-6147%2800%2901609-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1179%2F146532807X245634"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.1989.tb24174.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000203753"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000046529"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2F35051594"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cccn.2004.03.016"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02442075"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2800%2901368-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200009283431313"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.284.10.1244-a"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000153700"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1601-5223.1990.tb00088.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01715125"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2F0378-4347%2888%2980065-3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3109%2F03630268208996930"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159%2F000204216"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002%2Fajh.10143"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002%2Fajh.10010"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.7036344"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00230400"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood.V97.9.2568"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:49:52Z","timestamp":1745437792000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000320302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2010,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000320302","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}