{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:38:33Z","timestamp":1745469513645,"version":"3.40.4"},"reference-count":29,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2010,12,8]],"date-time":"2010-12-08T00:00:00Z","timestamp":1291766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,12,8]],"date-time":"2010-12-08T00:00:00Z","timestamp":1291766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Elevated parathyroid hormone (PTH) is used to diagnose high turnover bone disease in chronic kidney disease (CKD). The diagnostic accuracy of PTH in kidney transplant recipients with CKD is unknown. &lt;i&gt;Methods:&lt;\/i&gt; We examined kidney transplant recipients with CKD stages 3 (n = 498) and 4 (n = 141) to determine the sensitivity and specificity of the Kidney\/Dialysis Outcome Quality Initiative (K\/DOQI)-recommended PTH levels in detecting elevated serum \u03b2-CrossLaps (CTX) or osteocalcin (OC) levels. We performed receiver-operator curve analyses to determine CKD stage-specific PTH levels that provide optimal diagnostic accuracy. &lt;i&gt;Results:&lt;\/i&gt; PTH below the lower limits of the K\/DOQI ranges (35 and 70 pg\/ml in CKD stages 3 and 4, respectively) showed sensitivity of &gt;90% in diagnosing increases in biochemical markers. The upper limits (70 and 110 pg\/ml), however, showed poor specificity. A specificity of &gt;90% for detecting increased biochemical markers was seen with PTH of &gt;140 and &gt;240 pg\/ml in CKD stages 3 and 4, respectively. &lt;i&gt;Conclusion:&lt;\/i&gt; Currently applied cutoffs for PTH in kidney transplant recipients with CKD stages 3 and 4 do not appear to adequately detect increased biochemical markers of bone turnover. Diagnostic uncertainty exists in patients with CKD stage 3 and PTH between 35 and 140 pg\/ml, and CKD stage 4 and PTH between 70 and 240 pg\/ml.<\/jats:p>","DOI":"10.1159\/000320318","type":"journal-article","created":{"date-parts":[[2010,12,14]],"date-time":"2010-12-14T13:20:39Z","timestamp":1292332839000},"page":"c78-c85","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic Accuracy of Serum Parathyroid Hormone Levels in Kidney Transplant Recipients with Moderate-to-Advanced CKD"],"prefix":"10.1159","volume":"118","author":[{"given":"Csaba P.","family":"Kovesdy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miklos Z.","family":"Molnar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria 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