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Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Since the introduction of anti-TNF agents for the treatment of Crohn\u2019s disease there has been interest in the potential for treating ulcerative colitis with biological therapies. Early observational series suggested a benefit in the setting of severe, hospitalized patients. However, the recent completion of two large multi-center, double-blind placebo-controlled trials confirmed a role for infliximab for outpatients with refractory, moderate-severe disease with evidence for clinical remissions, mucosal healing, and a reduction in colectomies. Despite this evidence, there are numerous questions remaining regarding the optimal positioning in the setting of moderate-severe disease, potential benefits of concomitant immune suppression and the need for maintenance treatment after induction therapy. Additional clinical trials have demonstrated a less profound benefit for adalimumab at similar doses that are used in Crohn\u2019s disease. Other biological agents that have targeted T cells such as visiluzimab and abatacept were not demonstrated to be effective in controlled trials.<\/jats:p>","DOI":"10.1159\/000320408","type":"journal-article","created":{"date-parts":[[2010,9,30]],"date-time":"2010-09-30T07:36:01Z","timestamp":1285832161000},"page":"497-500","source":"Crossref","is-referenced-by-count":2,"title":["The Role of Biologics in Ulcerative Colitis"],"prefix":"10.1159","volume":"28","author":[{"given":"Stephen B.","family":"Hanauer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,9,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2036.2008.03606.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fajg.2009.727"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.2001.26279"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.2005.068809"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.305.6844.20"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cgh.2006.04.001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2036.2003.01686.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2002.06026.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2001.04039.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.52.7.998"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00042737-200411000-00014"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa050516"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2009.06.061"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fibd.20924"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2036.2008.03811.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038%2Fajg.2009.759"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2036.2008.03890.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clinthera.2008.02.014"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2036.2007.03300.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2036.2006.03131.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2005.08.040"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002%2Fmed.20103"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2005.03.003"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097%2F00054725-200105000-00001"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2005.11.037"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.gtc.2006.09.002"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2036.2009.04204.x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jamcollsurg.2006.12.044"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2006.01.047"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2036.2007.03415.x"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2009.02.001"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa042982"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2036.2006.02837.x"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320408","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:51:28Z","timestamp":1745437888000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000320408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000320408","archive":["Portico"],"relation":{},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"type":"print","value":"0257-2753"},{"type":"electronic","value":"1421-9875"}],"subject":[],"published":{"date-parts":[[2010]]}}}