{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:38:38Z","timestamp":1745469518060,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aim:&lt;\/i&gt; Recent studies have suggested a relation of homocysteine with lipid metabolism. The aim of this study was to analyze a possible genetic basis for such a relation in 504 individuals including 135 consecutive Caucasian patients diagnosed with cerebrovascular disease as well as the patients\u2019 healthy spouses (n = 100) and offspring (n = 269). &lt;i&gt;Methods:&lt;\/i&gt; We analyzed the association of plasma levels of lipoprotein(a), total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides with plasma homocysteine levels and with the following 7 variants of homocysteine metabolism: dihydrofolate reductase c.594 + 59del19bp, cystathionine \u03b2-synthase c.844_855ins68, methionine synthase c.2756A\u2192G, methylenetetrahydrofolate reductase c.677C\u2192T and c.1298A\u2192C, reduced folate carrier 1 c.80G\u2192A, and transcobalamin 2 (Tc2) c.776C\u2192G. &lt;i&gt;Results:&lt;\/i&gt; Linear regression analysis showed an association of Tc2 c.776C\u2192G with LDL (p = 0.010), HDL (p = 0.009), and TG (p = 0.007), with the G allele of Tc2 c.776C\u2192G associated with an unfavorable blood lipid profile. Moreover, the G allele of Tc2 c.776C\u2192G was associated with higher homocysteine plasma levels in the subgroup of patients (p = 0.013, 1-way ANOVA). &lt;i&gt;Conclusion:&lt;\/i&gt; These data support the hypothesis that alterations in homocysteine metabolism and an unfavorable blood lipoprotein profile may have a common genetic basis. Such conditions may be relevant for studies investigating independent risk factors for vascular disease.<\/jats:p>","DOI":"10.1159\/000320418","type":"journal-article","created":{"date-parts":[[2010,10,14]],"date-time":"2010-10-14T08:27:00Z","timestamp":1287044820000},"page":"112-115","source":"Crossref","is-referenced-by-count":2,"title":["The G Allele of Transcobalamin 2 c.776C\u2192G Is Associated with an Unfavorable Lipoprotein Profile"],"prefix":"10.1159","volume":"57","author":[{"given":"Alexander","family":"Semmler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Farmand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Moskau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Stoffel-Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Linnebank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,10,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.febslet.2009.03.038"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M406820200"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.274.19.1526"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0021-9150%2891%2990257-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI11596"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161%2F01.RES.0000242559.42077.22"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1152%2Fphysiolgenomics.00294.2007"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186%2F1476-511X-5-1"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000149936.33498.83"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000244764.02851.d3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093%2Fqjmed%2F94.3.159"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.thromres.2006.05.009"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Fhumu.20522"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2002-01-0209"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2F0021-9150%2889%2990200-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejphar.2007.07.022"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000090635"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1152%2Fajpendo.00518.2004"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M800830200"}],"container-title":["Annals of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:51:37Z","timestamp":1745437897000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000320418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,11,1]]},"published-print":{"date-parts":[[2010,11,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000320418","archive":["Portico"],"relation":{},"ISSN":["0250-6807","1421-9697"],"issn-type":[{"type":"print","value":"0250-6807"},{"type":"electronic","value":"1421-9697"}],"subject":[],"published":{"date-parts":[[2010]]}}}