{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:38:40Z","timestamp":1745469520668,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To describe a case of early-onset Alzheimer\u2019s disease (AD) in an apolipoprotein (Apo) &amp;#917;2\/&amp;#917;2 homozygote. &lt;i&gt;Background:&lt;\/i&gt; Apo &amp;#917;2\/&amp;#917;2 is the rarest of the ApoE genotypes, representing only 1.4% of the population. Cognitive decline in ApoE &amp;#917;2 homozygotes has rarely been reported. &lt;i&gt;Case Report\/Methods:&lt;\/i&gt; We report a 58-year-old Apo &amp;#917;2\/&amp;#917;2 female who meets clinical criteria for probable AD as confirmed by neuropsychological testing, positron emission\/computed tomography scan, CSF analysis and genetic screening for known mutations. &lt;i&gt;Results:&lt;\/i&gt; The clinical course is typical of AD, with progressive cognitive and functional decline. &lt;i&gt;Conclusion:&lt;\/i&gt; Clinically confirmed early-onset AD is atypical in ApoE2 homozygotes but can occur.<\/jats:p>","DOI":"10.1159\/000320589","type":"journal-article","created":{"date-parts":[[2010,10,25]],"date-time":"2010-10-25T07:43:19Z","timestamp":1287992599000},"page":"387-391","source":"Crossref","is-referenced-by-count":1,"title":["Probable Early-Onset Alzheimer\u2019s Disease in an Apolipoprotein E2 Homozygote"],"prefix":"10.1159","volume":"30","author":[{"given":"Lauren","family":"Cole","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Belden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Liebsack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent","family":"Myers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Reninger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camryn","family":"Berk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwan N.","family":"Sabbagh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,10,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.3283935"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.92.11.4725"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fng0694-180"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.64.8.1193"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3956%2875%2990026-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F89.4.815"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F85.4.665"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1037%2Fh0054651"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080%2F01688638008403793"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0278-2626%2892%2990112-Y"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001%2Farchpsyc.61.1.95"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1586%2F14737159.5.5.661"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.286.17.2120"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neurobiolaging.2005.04.008"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038%2Fng0996-55"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.21142"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038%2Ftpj.2009.69"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320589","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:52:21Z","timestamp":1745437941000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000320589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":17,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2010,12,1]]},"published-print":{"date-parts":[[2010,12,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000320589","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"type":"print","value":"1420-8008"},{"type":"electronic","value":"1421-9824"}],"subject":[],"published":{"date-parts":[[2010]]}}}