{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:49:21Z","timestamp":1761630561772,"version":"3.40.4"},"reference-count":23,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,9,17]],"date-time":"2010-09-17T00:00:00Z","timestamp":1284681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,9,17]],"date-time":"2010-09-17T00:00:00Z","timestamp":1284681600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; It is undetermined whether the effect of uric acid (UA) on graft outcome is independent of graft dysfunction. This study was designed to explore whether early-onset hyperuricemia has clinical significance regardless of graft function. &lt;i&gt;Methods:&lt;\/i&gt; This study was conducted based on a retrospective chart review. We calculated time-averaged UA and estimated glomerular filtration rate from the values at 3, 6, and 9 months after transplantation. Cardiovascular complications during follow-up and long-term graft survival were assessed according to UA levels and graft function. &lt;i&gt;Results:&lt;\/i&gt; 351 patients were enrolled into this study. Hyperuricemia increased the risk of cardiovascular complications (HR = 2.8, 95% CI 1.1\u20137.1; p = 0.02), but reduced graft function did not. In the hyperuricemia group, 5- and 10-year graft survival was significantly lower than in the normouricemia group (89 and 81% vs. 96 and 92%, respectively; p = 0.02). In the reduced graft function group, these values were also lower than in the normal graft function group (89 and 81% vs. 96 and 93%, respectively; p = 0.02). In the multivariate analysis, both hyperuricemia and reduced graft function were independent risk factors for graft failure and the presence of both factors presented the highest risk. &lt;i&gt;Conclusion:&lt;\/i&gt; Early-onset hyperuricemia is a significant predictor of cardiovascular complications and graft survival independently of graft function.<\/jats:p>","DOI":"10.1159\/000320743","type":"journal-article","created":{"date-parts":[[2010,9,17]],"date-time":"2010-09-17T07:48:02Z","timestamp":1284709682000},"page":"c276-c283","source":"Crossref","is-referenced-by-count":12,"title":["Clinical Significance of Early-Onset Hyperuricemia in Renal Transplant Recipients"],"prefix":"10.1159","volume":"117","author":[{"given":"Byung Ha","family":"Chung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok Hui","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeon Seok","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bum Soon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol Whee","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Il","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Sung","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul Woo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,9,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.29.3.635"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1291%2Fhypres.24.691"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.semnephrol.2004.10.001"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000045939"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2899%2970295-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjcard.2008.11.042"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2FTP.0b013e3181814f5b"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F01.tp.0000183895.88572.13"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.transproceed.2007.03.028"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1600-6143.2003.00315.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.7326%2F0003-4819-130-6-199903160-00002"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfp192"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.transproceed.2005.08.042"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-0012.2009.01023.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.transproceed.2005.09.101"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2002.00424.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfn621"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00273.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjcard.2005.07.068"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fehi879"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2005050572"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jss.2007.12.786"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097%2F01.TP.0000155305.49439.4C"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320743","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:53:59Z","timestamp":1745438039000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000320743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,17]]},"references-count":23,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,2,1]]},"published-print":{"date-parts":[[2011,2,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000320743","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"type":"electronic","value":"1660-2110"}],"subject":[],"published":{"date-parts":[[2010,9,17]]}}}