{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:05:54Z","timestamp":1761059154318,"version":"3.40.4"},"reference-count":33,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Asymptomatic aeroallergen sensitisation affects approximately 10% of Western adolescents and is an established risk factor for the development of respiratory allergy. The reported incidence is 2\u201320% annually. Previous studies are based on out-seasonal symptom recollection or selected populations, conferring bias towards higher incidence rates. &lt;i&gt;Objective:&lt;\/i&gt; The aim was to determine the incidence of onset of symptoms among clinically well-characterised asymptomatic, sensitised subjects compared with controls, and to evaluate the predictive values of common allergological tests. &lt;i&gt;Methods:&lt;\/i&gt; We performed a prospective, clinical, non-interventional, 2-year follow-up study on subjects (identified by population screening) with seasonal allergic birch or grass pollen rhinitis (n = 52), asymptomatic sensitisation to grass or birch (AS, n = 52) or non-atopic, healthy control subjects (n = 39). Experimental allergen susceptibility was assessed at inclusion and at follow-up by skin prick test, conjunctival challenge, intradermal late-phase reaction and measurement of specific IgE. Participants completed in-seasonal symptom and medication diaries during 2 subsequent seasons. &lt;i&gt;Results:&lt;\/i&gt; We observed an annual incidence rate of 5% for the onset of symptoms in the AS group (healthy control group 0%). At baseline, the AS group displayed intermediate experimental allergen susceptibility. Subjects developing symptoms had higher levels of specific IgE and larger late-phase reaction than those persistently asymptomatic. However, the positive predictive values were low (14\u201327%) in contrast to the negative predictive values (95\u2013100%). &lt;i&gt;Conclusion:&lt;\/i&gt; In a well-characterised young population, asymptomatic aeroallergen sensitisation conferred a low risk for onset of symptoms during the 2-year follow-up. Persistent asymptomatic phenotype could be accurately predicted by negative results from simple allergological testing.<\/jats:p>","DOI":"10.1159\/000320758","type":"journal-article","created":{"date-parts":[[2011,2,3]],"date-time":"2011-02-03T08:12:05Z","timestamp":1296720725000},"page":"289-296","source":"Crossref","is-referenced-by-count":11,"title":["A Prospective, Clinical Study on Asymptomatic Sensitisation and Development of Allergic Rhinitis: High Negative Predictive Value of Allergological Testing"],"prefix":"10.1159","volume":"155","author":[{"given":"Uffe","family":"Bodtger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"Assing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars K.","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,2,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-3038.2008.00805.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2006.01140.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2007.01517.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1399-3038.2003.00024.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2500%2F108854194778816634"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2002.12945.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2003.37"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00453546"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0021-8707%2858%2990009-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0021-8707%2869%2990024-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2005.05.017"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2006.02435.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2009.02169.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2006.01280.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2000.108312"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2006.01084.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2002.1o3532.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2004.00457.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.1993.tb04756.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.1984.tb01931.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2897%2970170-2"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2222.1999.00567.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2000.00367.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.1998.tb03954.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2222.2003.01611.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2F0304-3959%2893%2990079-5"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.spinee.2008.11.002"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1158%2F1055-9965.EPI-07-2629"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1398-9995.2003.00323.x"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.1992.tb02829.x"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2006.02594.x"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.2174%2F187152808786848405"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2249.2008.03712.x"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320758","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:54:04Z","timestamp":1745438044000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000320758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,6,1]]},"published-print":{"date-parts":[[2011,6,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000320758","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2011]]}}}