{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:34:28Z","timestamp":1770824068542,"version":"3.50.1"},"reference-count":24,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,11,26]],"date-time":"2010-11-26T00:00:00Z","timestamp":1290729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,11,26]],"date-time":"2010-11-26T00:00:00Z","timestamp":1290729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Objective:<\/i> Age-adjusted evaluations have explored the possible utility of human papillomavirus (HPV) test results in women with low-grade squamous intra-epithelial lesion (LSIL) Paps. We document LSIL correlation data with HPV test results and histopathologic follow-up from a large academic women\u2019s hospital practice. <i>Study Design:<\/i> LSIL Pap tests with intermediate-\/high-risk HPV DNA testing between July 1, 2005 and April 30, 2008 were studied along with follow-up histopathologic diagnoses. Patients were divided into age groups, and tissue diagnoses were correlated with HPV test results. <i>Results:<\/i> 1,083 (80.2%) of a total of 1,351 LSIL Pap samples tested HPV positive. HPV prevalence declined in older age groups. 719 women with LSIL Pap and HPV test results had at least 1 follow-up cervical biopsy result. 89 of 612 patients with HPV-positive LSIL (14.5%) had a follow-up histopathological diagnosis of cervical intra-epithelial neoplasia (CIN) 2\/3. Only 4 of 107 patients with HPV-negative LSIL (3.7%) had CIN 2\/3. <i>Conclusions:<\/i> In the largest study to date to document histopathological follow-up of older women with LSIL and HPV test results, no histopathological CIN 2\/3 diagnoses were identified in women 50 years and older with HPV-negative LSIL. HPV test results stratified women with LSIL cytology findings into lower- and higher-risk groups for follow-up histopathologic CIN 2\/3 outcomes.<\/jats:p>","DOI":"10.1159\/000320877","type":"journal-article","created":{"date-parts":[[2010,11,26]],"date-time":"2010-11-26T07:49:21Z","timestamp":1290757761000},"page":"48-53","source":"Crossref","is-referenced-by-count":24,"title":["HPV Test Results Stratify Risk for Histopathologic Follow-Up Findings of High-Grade Cervical Intra-Epithelial Neoplasia in Women with Low-Grade Squamous Intra-Epithelial Lesion Pap Results"],"prefix":"10.1159","volume":"55","author":[{"given":"Amer","family":"Heider","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Marshall","family":"Austin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengquan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,11,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.287.16.2120"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00006250-200612000-00060"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3322%2Fcanjclin.57.2.105"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2F92.5.397"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajog.2007.07.047"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejca.2006.11.013"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMp020178"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS1473-3099%2807%2970158-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0959-8049%2801%2900374-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2FAOG.0b013e318192497c"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.22949"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.21940"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.22865"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ygyno.2005.07.033"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.vaccine.2006.05.117"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1067%2Fmob.2003.457"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2Fdjj209"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.21664"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1086%2F428779"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2Fdjj009"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3109%2F01674829809025694"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1067%2Fmob.2003.462"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajog.2006.01.091"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.23969"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320877","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:55:04Z","timestamp":1745438104000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000320877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,26]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,2,1]]},"published-print":{"date-parts":[[2010,12,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000320877","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"value":"0001-5547","type":"print"},{"value":"1938-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,26]]}}}