{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:45:00Z","timestamp":1760298300793,"version":"3.40.4"},"reference-count":8,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,11,26]],"date-time":"2010-11-26T00:00:00Z","timestamp":1290729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,11,26]],"date-time":"2010-11-26T00:00:00Z","timestamp":1290729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Rapid pre-screening (RPS) is a useful tool to measure and improve performance in the cytology laboratory. Whether RPS is more or less effective in liquid-based cytology than in conventional smears is unknown. We compared the estimated sensitivity in a laboratory of 11 cytotechnologists which converted from conventional smears to SurePath\u2122 (Becton Dickinson, Franklin Lakes, N.J., USA) liquid based cytology. In the 9 months prior to conversion, 23,286 smears were screened compared with 30,610 smears in the 12 months immediately after conversion. The estimated sensitivity of rapid pre-screening for 90 s improved significantly with liquid based cytology for all abnormalities (58.7 vs. 68.7%, p &lt; 0.001), atypical squamous cells of undetermined significance + low-grade squamous intra-epithelial lesion (52.6 vs. 63.1%, p &lt; 0.001), and high-grade squamous intra-epithelial alone (76.2 vs. 85%, p &lt; 0.001). Histologic follow up for 156 cases identified by rapid pre-screening of SurePath slides showed 32 (21%) cases of CIN1 or greater and 18 cases (12%) with CIN3 or worse. We conclude that rapid pre-screening is significantly more sensitive in liquid-based cytology compared with conventional smears, and detects significant lesions that are missed by routine screening.<\/jats:p>","DOI":"10.1159\/000320906","type":"journal-article","created":{"date-parts":[[2010,11,26]],"date-time":"2010-11-26T07:49:21Z","timestamp":1290757761000},"page":"54-56","source":"Crossref","is-referenced-by-count":7,"title":["Rapid Pre-Screening Is More Sensitive in Liquid-Based Cytology than in Conventional Smears"],"prefix":"10.1159","volume":"55","author":[{"given":"Nick","family":"Dudding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew A.","family":"Renshaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kay","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,11,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2303.2001.00340.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0339%28200103%2924%3A3%3C219%3A%3AAID-DC1045%3E3.0.CO%3B2-Z"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2303.1995.tb00453.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2303.2002.00410.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2303.2003.00062.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.21424"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2303.2008.00562.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncy.20042"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320906","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:55:30Z","timestamp":1745438130000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000320906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,26]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,2,1]]},"published-print":{"date-parts":[[2010,12,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000320906","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"type":"print","value":"0001-5547"},{"type":"electronic","value":"1938-2650"}],"subject":[],"published":{"date-parts":[[2010,11,26]]}}}