{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:26:20Z","timestamp":1778639180374,"version":"3.51.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; The usefulness of 2 novel biomarkers in pancreatic surgical and cytological specimens that could reliably differentiate non-neoplastic pancreatic duct and benign gut epithelium from pancreatic ductal adenocarcinoma (PDA) was evaluated. &lt;i&gt;Study Design:&lt;\/i&gt; A total of 14 pancreatic resection specimens (RSs), 23 endoscopic ultrasound-guided fine needle aspirations (EUS-FNAs) of PDA and 8 benign pancreatic EUS-FNAs were selected. Twelve of 14 RSs had corresponding EUS-FNAs with cell blocks (CBs). Non-neoplastic pancreatic tissue, including chronic pancreatitis, was evaluated in all RSs. Immunohistochemical stains for S100P and X-linked inhibitor of apoptosis protein (XIAP) were performed on tissue and CB sections. Staining intensity (0 no staining; 1+ weak; 2+ moderate; 3+ strong) and proportion of positive cells (less than 10% negative; 1+ 10\u201325%; 2+ 26\u201375%; 3+ greater than 75%) were assessed. Positive staining was defined as \u226710% cells with at least 1+ intensity. &lt;i&gt;Results:&lt;\/i&gt; The sensitivity and specificity of S100P and XIAP immunoreactivity for a diagnosis of PDA in RSs were both 100%. In contrast, the sensitivity and specificity in EUS-FNA CBs of S100P were 78.2 and 87.5% and of XIAP 82.6 and 50.0%, respectively. The combined sensitivity of S100P and XIAP was 100% in 12 RSs and 83.3% in the corresponding EUS-FNA CBs. &lt;i&gt;Conclusion:&lt;\/i&gt; Two novel biomarkers have very high sensitivity and specificity in the diagnosis of PDA in RSs. S100P has slightly lower sensitivity and higher specificity of PDA than XIAP in EUS-FNA specimens. We recommend using both biomarkers as cytological diagnostic adjuncts, especially in difficult cases of well-differentiated PDA versus reactive ductal epithelium.<\/jats:p>","DOI":"10.1159\/000320913","type":"journal-article","created":{"date-parts":[[2011,2,17]],"date-time":"2011-02-17T09:40:29Z","timestamp":1297935629000},"page":"142-148","source":"Crossref","is-referenced-by-count":24,"title":["S100P and XIAP Expression in Pancreatic Ductal Adenocarcinoma: Potential Novel Biomarkers as a Diagnostic Adjunct to Fine Needle Aspiration Cytology"],"prefix":"10.1159","volume":"55","author":[{"given":"Ognjen","family":"Kosarac","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiro","family":"Takei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qihui Jim","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary R.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina R.","family":"Mody","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,2,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322%2Fcaac.20006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000325470"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F01.pas.0000149688.98333.54"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2FMPA.0b013e318150e4e0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fdc.20624"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1309%2F5D76NDE81LE8G545"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cgh.2008.08.010"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00000478-200606000-00013"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2FPAS.0b013e31815701f3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.11857"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1309%2FWF03-NFCE-7BRH-7C26"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2002.12.063"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.23254"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1158%2F1078-0432.CCR-05-0092"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9440%2810%2962234-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1207269"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F00001813-199804000-00004"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2Fpath.1418"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038%2F35080103"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.22554"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097%2F01.mpa.0000218314.67111.fb"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.11012"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:55:33Z","timestamp":1745438133000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000320913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,4,1]]},"published-print":{"date-parts":[[2011,2,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000320913","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"value":"0001-5547","type":"print"},{"value":"1938-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}