{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T10:34:46Z","timestamp":1764239686339,"version":"3.40.4"},"reference-count":55,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Hered"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Bipolar disorder (BP) is a severe psychiatric illness, characterised by alternating episodes of depression and mania, which ranks among the top ten causes of morbidity and life-long disability world-wide. We have previously performed a whole-genome linkage scan on 6 pedigrees segregating severe BP from the well-characterised population isolate of Antioquia, Colombia. We recently collected genotypes for the same set of 382 autosomal microsatellite markers in 9 additional Antioquian BP pedigrees. Here, we report the analysis of the combined pedigree set. &lt;i&gt;Methods:&lt;\/i&gt; Linkage analysis using both parametric and nonparametric approaches was conducted for 3 different diagnostic models: severe BP only (BPI); mood disorders (BPI, BPII and major depression); and psychosis (operationally defined by the occurrence of at least 1 episode of hallucinations and\/or delusions). &lt;i&gt;Results and Conclusion:&lt;\/i&gt; For BPI only, the most interesting result was obtained for chromosome 7p21.1\u2013p22.2 under a recessive model of inheritance (heterogeneity LOD score = 2.80), a region that had previously been linked to BP in a study on Portuguese Island families. For both BPI and mood disorders, nonparametric analyses identified a locus on chromosome 12ct\u2013q14 (nonparametric linkage = 2.55 and 2.35, respectively). This locus has not previously been reported as a candidate region for BP. Additional candidate regions were found on chromosomes 1p22\u201331 (mood disorders) and 21q21\u201322 (BPI), 2 loci that have repeatedly been implicated in BP susceptibility. Linkage analysis of psychosis as a phenotype identified candidate regions on chromosomes 2q24\u201331 and 16p12\u2013q12. The finding on chromosome 16p is noteworthy because the same locus has been implicated by genome-wide association analyses of BP.<\/jats:p>","DOI":"10.1159\/000320914","type":"journal-article","created":{"date-parts":[[2010,11,10]],"date-time":"2010-11-10T07:59:46Z","timestamp":1289375986000},"page":"255-268","source":"Crossref","is-referenced-by-count":20,"title":["Genome-Wide Linkage Scan of Bipolar Disorder in a Colombian Population Isolate Replicates Loci on Chromosomes 7p21\u201322, 1p31, 16p12 and 21q21\u201322 and Identifies a Novel Locus on Chromosome 12q"],"prefix":"10.1159","volume":"70","author":[{"given":"B.","family":"Kremeyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.W.","family":"Burley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Herzberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.V.","family":"Parra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Duque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Vega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Montoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Bedoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Reus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Palacio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ospina-Duque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.B.","family":"Freimer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ruiz-Linares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,11,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2802%2907450-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.c.20013"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature05911"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.mp.4002151"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0508716103"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2Fddl254"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.b.30956"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-8628%2819960531%2967%3A3%3C254%3A%3AAID-AJMG3%3E3.0.CO%3B2-N"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1086%2F301904"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1086%2F338920"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.93.23.13060"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.mp.4001254"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Fbioinformatics%2Fbti364"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.96.10.5604"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2Fddg199"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.biopsych.2003.08.001"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1086%2F498619"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.b.30524"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.mp.4001541"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.mp.4001778"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093%2Fschbul%2Fsbj033"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-8628%2819991015%2988%3A5%3C567%3A%3AAID-AJMG24%3E3.0.CO%3B2-8"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ypg.0000128766.92096.ad"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.011358498"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.mp.4001267"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1086%2F491602"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-5618.2007.00388.x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038%2F1734"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.182412499"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1086%2F374822"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.mp.4001421"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.mp.4001074"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-8628%28199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