{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:59:07Z","timestamp":1789732747570,"version":"4.0.1"},"reference-count":10,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Due to its increased non-susceptibility rates, &lt;i&gt;Klebsiella pneumoniae&lt;\/i&gt; has emerged as one of the most problematic pathogens. &lt;i&gt;Methods:&lt;\/i&gt; The level of resistance to 25 antimicrobials of &lt;i&gt;K. pneumoniae&lt;\/i&gt; isolates from a teaching hospital in Greece and the evolution trends during 2 decades were examined. &lt;i&gt;Results:&lt;\/i&gt; A statistically significant increase in non-susceptibility rates was found for almost all antimicrobials examined. During 2008, the isolates presented non-susceptibility rates to aminoglycosides &gt;50% and to quinolones &gt;60%. Nowadays, 1 out of 10 isolates is non-susceptible to colistin. Moreover, the isolates non-susceptible to imipenem were almost doubled between 2007 (29%) and 2008 (50%). Among the imipenem-resistant isolates, 1 out of 4 was also resistant to colistin. &lt;i&gt;Conclusion:&lt;\/i&gt; The effectiveness of carbapenems has been compromised and the increase in resistance to colistin is rapid and steep.<\/jats:p>","DOI":"10.1159\/000320943","type":"journal-article","created":{"date-parts":[[2010,11,18]],"date-time":"2010-11-18T08:00:04Z","timestamp":1290067204000},"page":"448-452","source":"Crossref","is-referenced-by-count":35,"title":["Resistance Status and Evolution Trends of &lt;i&gt;Klebsiella pneumoniae&lt;\/i&gt; Isolates in a University Hospital in Greece: Ineffectiveness of Carbapenems and Increasing Resistance to Colistin"],"prefix":"10.1159","volume":"56","author":[{"given":"I.K.","family":"Neonakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Samonis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Messaritakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Baritaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Georgiladakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Maraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.A.","family":"Spandidos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,11,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2FQCO.0b013e328303670b"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jinf.2009.01.010"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000118661"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.diagmicrobio.2003.09.012"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0924-8579%2803%2900152-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijantimicag.2008.02.013"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS1473-3099%2806%2970580-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2FCCM.0B013E3181652FAE"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000112415"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000118660"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320943","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320943","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:55:45Z","timestamp":1745438145000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000320943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":10,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2010,12,1]]},"published-print":{"date-parts":[[2010,12,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000320943","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}