{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:38:50Z","timestamp":1745469530097,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; It is not clear whether tissue plasminogen activator (t-PA) thrombolysis in patients without major arterial occlusion is effective or safe. &lt;i&gt;Methods:&lt;\/i&gt; Consecutive anterior circulation stroke patients treated with t-PA within 3 h of onset were studied. The patients were divided into three groups according to magnetic resonance angiography findings before t-PA infusion: ICA group, ICA occlusion; MCA group, M1 and M2 occlusion, and no occlusion group. Clinical characteristics, the presence of hemorrhagic transformation on T&lt;sub&gt;2&lt;\/sub&gt;* at 24 h after t-PA thrombolysis, and outcome at 3 months were compared among the three groups. &lt;i&gt;Results:&lt;\/i&gt; 112 patients were enrolled. The no occlusion group had 21 (18.8%) patients, the ICA group had 29 (25.9%), and the MCA group had 62 (55.4%). The frequency of hemorrhagic transformation was only 4.8% in the no occlusion group (31.0% for the ICA group, and 48.4% for the MCA group, p = 0.0012). At 3 months after t-PA therapy, 61.5% of the no occlusion group had a favorable outcome (modified Rankin score 0\u20131), which was the highest among the three groups (15.0% for the ICA group, and 41.5% for the MCA group, p = 0.0203). &lt;i&gt;Conclusion:&lt;\/i&gt; Intravenous t-PA therapy in acute stroke patients without major artery occlusion seems to be safe and effective.<\/jats:p>","DOI":"10.1159\/000320950","type":"journal-article","created":{"date-parts":[[2010,10,15]],"date-time":"2010-10-15T07:00:47Z","timestamp":1287126047000},"page":"258-264","source":"Crossref","is-referenced-by-count":2,"title":["Intravenous Tissue Plasminogen Activator Thrombolysis in Patients without Major Arterial Occlusion Seems to Be Safe and Effective"],"prefix":"10.1159","volume":"64","author":[{"given":"Kazumi","family":"Kimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Iguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensaku","family":"Shibazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,10,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199512143332401"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000257977.32525.6e"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000160007.57787.4c"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000106485.04500.4A"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161%2FSTROKEAHA.109.573477"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000170711.43405.81"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.283.9.1145"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa0804656"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.274.13.1017"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2898%2908020-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2807%2960149-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000227191.01792.e3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161%2FSTROKEAHA.106.480475"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.2004.059261"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199903183401117"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.39.9.1246"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320950","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320950","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:56:02Z","timestamp":1745438162000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000320950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":16,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2010,11,1]]},"published-print":{"date-parts":[[2010,11,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000320950","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"type":"print","value":"0014-3022"},{"type":"electronic","value":"1421-9913"}],"subject":[],"published":{"date-parts":[[2010]]}}}