{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:11:37Z","timestamp":1780445497517,"version":"3.54.1"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,11,2]],"date-time":"2010-11-02T00:00:00Z","timestamp":1288656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,11,2]],"date-time":"2010-11-02T00:00:00Z","timestamp":1288656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Introduction:<\/i> Hydronephrosis and BMI are analyzed together with established factors such as TNM stage and surgical margins in a multivariate modality to investigate their status as independent prognostic factors for bladder cancer-specific survival in patients undergoing radical cystectomy. <i>Patients and Methods:<\/i> We studied a prospective cohort of 328 patients who underwent radical cystectomy for bladder cancer at our institution. Statistical analyses were performed using the Kaplan-Meier method, Kendall-tau rank correlation and multivariate Cox proportional hazard model. <i>Results:<\/i> Hydronephrosis was positively correlated with advanced tumor stage, positive lymph node involvement and positive surgical margins. Adjusted for all other investigated parameters, BMI and hydronephrosis did not affect cancer-specific survival. In multivariate analysis only non-organ-confined disease (HR: 1.40, 95% CI: 1.04\u20131.87, p = 0.024), positive lymph node stage (HR 1.71: 95% CI: 1.12\u20132.61, p = 0.013) and positive surgical margins (HR 3.00, 95% CI: 1.74\u20135.15, p < 0.001) were prognostic factors. <i>Conclusions:<\/i> Hydronephrosis at the time of radical cystectomy is significantly correlated with the presence of more advanced bladder cancer and positive surgical margins. However, the long-established parameters pT stage, pN stage and surgical margins predominantly influence cancer-specific survival for patients undergoing radical cystectomy irrespective of hydronephrosis and BMI status.<\/jats:p>","DOI":"10.1159\/000321008","type":"journal-article","created":{"date-parts":[[2011,2,9]],"date-time":"2011-02-09T08:44:06Z","timestamp":1297241046000},"page":"25-30","source":"Crossref","is-referenced-by-count":11,"title":["Preoperative Hydronephrosis Predicts Advanced Bladder Cancer but Is Not an Independent Factor for Cancer-Specific Survival after Radical Cystectomy"],"prefix":"10.1159","volume":"86","author":[{"given":"Thomas","family":"Hofner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Haferkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Knapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Pahernik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Hadaschik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nenad","family":"Djakovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Wagener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hohenfellner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,11,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.juro.2008.03.024"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.juro.2006.03.038"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2006.07.009"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa055643"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa021423"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ju.0000154352.54965.14"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000218533"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ju.0000138785.48347.aa"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.urology.2006.11.012"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fjso.2930520109"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000241668"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.urology.2008.03.053"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2801%2962228-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.juro.2007.08.023"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00345-008-0345-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2009.01.004"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/321008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/321008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:55:46Z","timestamp":1745434546000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000321008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,2]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,2,1]]},"published-print":{"date-parts":[[2011,2,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000321008","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,2]]}}}