{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:10:39Z","timestamp":1761743439995,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,11,17]],"date-time":"2010-11-17T00:00:00Z","timestamp":1289952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,11,17]],"date-time":"2010-11-17T00:00:00Z","timestamp":1289952000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; To evaluate acoustic overstimulation-induced spiral ganglion cell (SGC) degeneration, and determine the relationship between the duration of acoustic overstimulation and rate of SGC degeneration. &lt;i&gt;Methods:&lt;\/i&gt; Fifteen guinea pigs were randomized equally to 4 experimental groups, which were exposed to different durations (7.5, 15, 30 and 60 min) of acoustic overstimulation (120 dB at 4 kHz), and a control group. Every bulla was examined histopathologically and immunohistochemically. A quantitative and statistical analysis of acidophilic and TUNEL-positive SGCs was performed. &lt;i&gt;Results:&lt;\/i&gt; In the control group, 2.1% of SGCs were acidophilic and no TUNEL-positive SGC was detected. In contrast, a statistically significant number of acidophilic (p = 0.000) and TUNEL-positive SGCs (p = 0.002) was determined in the experimental groups. Moreover, a positive correlation between the duration of acoustic overstimulation and acidophilic SGCs (p = 0.000), and a statistically significant relationship between the duration of acoustic overstimulation and TUNEL-positive SGCs (p = 0.000) were demonstrated. &lt;i&gt;Conclusion:&lt;\/i&gt; Acoustic overstimulation may induce acute SGC degeneration. A positive correlation was determined between the duration of acoustic overstimulation and rate of degenerated SGCs.<\/jats:p>","DOI":"10.1159\/000321116","type":"journal-article","created":{"date-parts":[[2010,11,17]],"date-time":"2010-11-17T07:42:08Z","timestamp":1289979728000},"page":"24-30","source":"Crossref","is-referenced-by-count":7,"title":["Acute Spiral Ganglion Cell Degeneration following Acoustic Overstimulation: An Experimental Study"],"prefix":"10.1159","volume":"73","author":[{"given":"G\u00f6rkem","family":"Eskiizmir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Vefa","family":"Y\u00fccet\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevin\u00e7","family":"\u0130nan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seren G\u00fcl\u015fen","family":"G\u00fcrgen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,11,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000046864"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS1357-4310%2898%2901285-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109%2F00016489309135762"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-5955%2800%2900020-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0385-8146%2800%2900117-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004050100388"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3109%2F00016487609120865"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0378-5955%2883%2990031-X"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs101620020028"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F00129492-200311000-00028"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080%2F000164800760370774"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-5955%2802%2900286-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080%2F00207450590956549"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.119.3.493"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3109%2F00016480903428200"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2F0301-0082%2895%2900028-3"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/321116","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/321116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:57:11Z","timestamp":1745434631000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000321116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,17]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,1,1]]},"published-print":{"date-parts":[[2011,1,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000321116","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"type":"print","value":"0301-1569"},{"type":"electronic","value":"1423-0275"}],"subject":[],"published":{"date-parts":[[2010,11,17]]}}}