{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:08:50Z","timestamp":1790986130531,"version":"4.1.0"},"reference-count":19,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Background\/Aims:<\/i> The <i>NOS3 <\/i>gene is a biological and positional candidate for diabetic nephropathy. However, the relationship between <i>NOS3 <\/i>polymorphisms and renal disease is inconclusive. This study aimed to clarify the association of <i>NOS3<\/i> variants with nephropathy in individuals with type 1 diabetes. <i>Methods:<\/i>We conducted a case-control study examining all common SNPs in the <i>NOS3<\/i> gene by a tag SNP approach. Individuals with type 1 diabetes and persistent proteinuria (cases, n = 718) were compared with individuals with type 1 diabetes but no evidence of renal disease (controls, n = 749). Our replication collection comprised 1,105 individuals with type 1 diabetes recruited to a nephropathy case group and 862 control individuals with normal urinary albumin excretion rates. Meta-analysis was conducted for SNPs where more than three genotype datasets were available. <i>Results:<\/i> A novel association was identified in the discovery collection (rs1800783, p<sub>genotype<\/sub> = 0.006, p<sub>allele<\/sub> = 0.002, OR = 1.26, 95% CI: 1.08\u20131.47) and supported by independent replication using a tag SNP (rs4496877, pairwise r<sup>2<\/sup> = 0.96 with rs1800783) in the replication collection (p<sub>genotype<\/sub> = 0.002, p<sub>allele<\/sub> = 0.0006, OR = 1.27, 95% CI: 1.10\u20131.45). <i>Conclusion:<\/i> The A allele of rs1800783 is a significant risk factor for nephropathy in individuals with type 1 diabetes, and further comprehensive studies are warranted to confirm the definitive functional variant in the <i>NOS3<\/i> gene.<\/jats:p>","DOI":"10.1159\/000321340","type":"journal-article","created":{"date-parts":[[2010,10,20]],"date-time":"2010-10-20T07:30:05Z","timestamp":1287559805000},"page":"476-481","source":"Crossref","is-referenced-by-count":14,"title":["Genetic Polymorphisms in Nitric Oxide Synthase 3 Gene and Implications for Kidney Disease: A Meta-Analysis"],"prefix":"10.1159","volume":"32","author":[{"given":"A.J.","family":"McKnight","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.C.","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Sandholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kilner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.A.","family":"Buckham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Parkkonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Forsblom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.M.","family":"Sadlier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.H.","family":"Groop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.P.","family":"Maxwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"and the Warren 3\/UK GoKinD Study 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