{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:42:16Z","timestamp":1791164536823,"version":"4.1.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Background\/Aims:<\/i> The present study examined the relationship between microvascular complications and cognitive decline and the development of structural brain abnormalities over a period of 4 years in patients with type 2 diabetes mellitus (T2DM). <i>Methods:<\/i> Sixty-eight elderly patients with T2DM had 2 cognitive assessments with a 4-year interval. Two MRI scans, performed at the same time as the cognitive assessments, were available from 55 patients. Changes in cognitive performance over time were expressed as a regression-based index (RBI). Automated volumetric measurements of total brain, lateral ventricles and white matter hyperintensities were performed. The relationship between baseline microvascular complications [diabetic retinopathy, peripheral neuropathy or albuminuria (micro- or macroalbuminuria)] and cognition and brain volumes was examined with linear regression analyses adjusted for age and sex (for cognition also for IQ). <i>Results:<\/i> At baseline, diabetic retinopathy was present in 18% of patients, peripheral neuropathy in 36%, albuminuria in 15%. Retinopathy or neuropathy were not significantly associated with baseline cognition or brain volumes, or changes in these measures over time. Albuminuria was associated with a lower composite RBI score, indicating accelerated cognitive decline (adjusted mean difference between patients with or without albuminuria: \u20130.58, 95% CI \u20130.85 to \u20130.31, p < 0.001). <i>Conclusion: <\/i>Albuminuria predicted accelerated cognitive decline in patients with T2DM, but other microvascular complications were unrelated to accelerated cognitive decline or brain MRI abnormalities.<\/jats:p>","DOI":"10.1159\/000321354","type":"journal-article","created":{"date-parts":[[2010,10,21]],"date-time":"2010-10-21T06:55:38Z","timestamp":1287644138000},"page":"381-386","source":"Crossref","is-referenced-by-count":56,"title":["Microvascular Determinants of Cognitive Decline and Brain Volume Change in Elderly Patients with Type 2 Diabetes"],"prefix":"10.1159","volume":"30","author":[{"given":"Jeroen","family":"de Bresser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael D.","family":"Reijmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marja A.","family":"Breedijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Jaap","family":"Kappelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max A.","family":"Viergever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert Jan","family":"Biessels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Utrecht Diabetic Encephalopathy Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,10,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2808%2970021-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.55.04.06.db05-1323"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2008.08.022"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2337%2Fdc09-1923"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00125-009-1571-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1017%2FS1355617799544068"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuroimage.2005.05.046"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1185%2F03007990802061818"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2337%2Fdc08-0562"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0168-8227%2801%2900300-X"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00125-007-0792-z"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00125-006-0283-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00392-007-0510-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.51.4.1157"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fgps.1523"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.63.5.noc60013"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/321354","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/321354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:58:44Z","timestamp":1745434724000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000321354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":16,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2010,12,1]]},"published-print":{"date-parts":[[2010,12,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000321354","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}