{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:19:08Z","timestamp":1775175548159,"version":"3.50.1"},"reference-count":8,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intervirology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Spontaneous preterm birth is the leading cause of perinatal morbidity and mortality. In this study the spontaneous preterm birth rates in a group of hepatitis B e antigen (HBeAg)-negative chronic hepatitis B virus (HBV)-infected pregnant women without known risk factors for preterm delivery as well as the role of maternal laboratory data and hepatitis B surface antigen\/HBV deoxyribonucleic acid (HBV-DNA) in cord blood in respect to preterm labour were evaluated. 138 consecutive HBeAg-negative chronic HBV-infected pregnant women were evaluated during the perinatal period. Serum HBV-DNA was determined by using the Cobas Amplicor HBV Test in both maternal and cord blood samples. 102 women were finally evaluated (36 were excluded) and 15 of them (14.7%) had spontaneous preterm birth. A significant association between spontaneous preterm birth and HBV-DNA in cord blood was observed (p = 0.007). HBV-DNA positivity in cord blood was significantly associated with maternal HBV-DNA levels (p = 0.002). The relative risk of HBV-DNA in cord blood was 6.43 times higher among women with serum HBV-DNA \u226710,000 copies\/ml and lymphocyte count &lt;1,500 compared to those with all the other combinations of both parameters (p = 0.001). In conclusion, the presence of HBV-DNA in cord blood is significantly associated with spontaneous preterm birth in chronic HBV-infected pregnant women. Women with HBV-DNA \u226710,000 copies\/ml and lymphocyte count &lt;1,500 during the perinatal period have a higher probability of HBV-DNA in their cord blood.<\/jats:p>","DOI":"10.1159\/000321356","type":"journal-article","created":{"date-parts":[[2011,8,16]],"date-time":"2011-08-16T08:34:09Z","timestamp":1313483649000},"page":"300-304","source":"Crossref","is-referenced-by-count":13,"title":["Presence of HBV-DNA in Cord Blood Is Associated with Spontaneous Preterm Birth in Pregnant Women with HBeAg-Negative Chronic Hepatitis B Virus Infection"],"prefix":"10.1159","volume":"54","author":[{"given":"Ioannis S.","family":"Elefsiniotis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miltos","family":"Papadakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Vlachos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Vezali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Tsoumakas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Saroglou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aristidis","family":"Antsaklis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,2,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2808%2960074-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10096-006-0190-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200005183422007"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bpobgyn.2007.01.008"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jhep.2005.05.023"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jhep.2007.02.014"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-1999-6802"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000219852"}],"container-title":["Intervirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/321356","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/321356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:58:45Z","timestamp":1745434725000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000321356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":8,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2011,8,1]]},"published-print":{"date-parts":[[2011,8,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000321356","archive":["Portico"],"relation":{},"ISSN":["0300-5526","1423-0100"],"issn-type":[{"value":"0300-5526","type":"print"},{"value":"1423-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}