{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:08:38Z","timestamp":1787314118012,"version":"build-2736575974"},"reference-count":22,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The prognosis of functional disability in patients with cerebrovascular disease has not been well established. Therefore, we conducted this study to determine the prognostic significance of high-sensitivity C-reactive protein (hs-CRP) and homocysteine (Hcy) levels in patients with functional disability after acute first-ever ischemic stroke. &lt;i&gt;Method:&lt;\/i&gt; A total of 309 patients with first-ever stroke were examined within 24 h after symptom onset. Hcy was measured at admission, and hs-CRP measurements were made at admission and on the seventh hospital day. The correlations between the concentration of hs-CRP or Hcy and functional disability at 1, 3, 6 and 12 months after stroke onset were analyzed. &lt;i&gt;Results:&lt;\/i&gt; The present study showed that both hs-CRP values on admission and on the seventh hospital day were significantly correlated with modified Rankin Scale (mRS) scores obtained at 4 times after the onset of stroke. These results also demonstrated that mRS scores are more closely associated with hs-CRP values on the seventh hospital day than on admission. However, there was no significant relationship between Hcy and mRS scores during the 12-month follow-up period. &lt;i&gt;Conclusion:&lt;\/i&gt; According to the present study, we cautiously suggest that hs-CRP values on the subacute phase have sufficient value as a predictor of the prognosis of functional disability after first-ever stroke.<\/jats:p>","DOI":"10.1159\/000321415","type":"journal-article","created":{"date-parts":[[2010,11,8]],"date-time":"2010-11-08T03:53:06Z","timestamp":1289188386000},"page":"304-310","source":"Crossref","is-referenced-by-count":28,"title":["Can High-Sensitivity C-Reactive Protein and Plasma Homocysteine Levels Independently Predict the Prognosis of Patients with Functional Disability after First-Ever Ischemic Stroke?"],"prefix":"10.1159","volume":"64","author":[{"given":"In-Uk","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Do","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joong-Seok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Soo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Woo","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,11,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.277.22.1775"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijcard.2006.06.053"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199707243370403"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.160.12.1834"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000231872.86071.68"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000089920.93927.A7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.104.506337"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200003233421202"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000125527.41598.68"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000029828.51413.82"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0404.2006.00715.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2801%2902190-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-2377-4-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000165929.78756.ed"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.106.649939"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199408183310701"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2898%2900136-3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200010193431602"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1155%2F2007%2F15929"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097%2F00019052-200102000-00015"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.atherosclerosis.2007.09.029"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000131942.77635.2D"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/321415","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/321415","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/321415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:59:25Z","timestamp":1745420365000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000321415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2010,11,1]]},"published-print":{"date-parts":[[2010,11,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000321415","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}