{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:36:05Z","timestamp":1745469365622,"version":"3.40.4"},"reference-count":31,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Background\/Aims:<\/i> A structural and functional interaction between A<sub>2A<\/sub> adenosine receptors and D<sub>2<\/sub> dopamine receptors has been implicated in the pathophysiology of impulse control disorders. The aim of this study was to use platelet membranes to assess A<sub>2A<\/sub> adenosine receptor affinity and density in patients affected by pathological gambling (PG; which is classified as a specific impulse control disorder) with respect to those of control subjects. <i>Methods:<\/i> Twelve drug-free PG patients and 12 age- and sex-matched healthy controls were enrolled in the study. PG was diagnosed according to the Structured Clinical Interview for DSM-IV \u2013 Patient Version 2.0 and the South Oaks Gambling Screen. A<sub>2A<\/sub> adenosine receptor binding parameters were evaluated using a [<sup>3<\/sup>H]ZM<sub>241385<\/sub> binding assay; affinity and density (B<sub>max<\/sub>) were determined by means of saturation binding studies with platelet membranes. <i>Results:<\/i> The A<sub>2A<\/sub> adenosine receptor binding affinity was found to be significantly higher in patients affected by PG than in healthy subjects; in contrast, no significant differences in B<sub>max<\/sub> were observed between the 2 groups. <i>Conclusions: <\/i>The elevated A<sub>2A<\/sub> adenosine receptor binding affinity in platelets from PG patients with respect to control subjects demonstrates for the first time a change in adenosine receptor parameters, and it suggests the involvement of the adenosine system in this pathology. The previously demonstrated hyperactivity of the dopamine system in PG may modulate the A<sub>2A<\/sub> adenosine receptor, supporting a role for this receptor as a peripheral marker of dopamine dysfunction. Because it is not possible to directly measure the D<sub>2<\/sub> dopamine receptor in human platelets, these data are particularly relevant to the detection of dopamine dysfunction.<\/jats:p>","DOI":"10.1159\/000321592","type":"journal-article","created":{"date-parts":[[2011,1,13]],"date-time":"2011-01-13T08:46:35Z","timestamp":1294908395000},"page":"154-159","source":"Crossref","is-referenced-by-count":1,"title":["A<sub>2A<\/sub> Adenosine Receptor Binding Parameters in Platelets from Patients Affected by Pathological 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