{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:59:32Z","timestamp":1791331172526,"version":"4.3.1"},"reference-count":11,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Background:<\/i> Vitamin A deficiency (VAD) is a nutritional problem affecting the health of people in developing countries because VAD compromises innate and adaptive immunity, increasing a person\u2019s predisposition toward infectious diseases. In addition, a high prevalence of infectious diseases continues to be a problem in developing countries, including <i>Giardia lamblia. G. lamblia<\/i> may be related to VAD because of its ability to change the intestinal architecture, thereby compromising the absorption of vitamin A. The aim of this study was to evaluate the effect of giardiasis on serum retinol levels and vitamin A liver stores in school children. <i>Methods:<\/i> Thirty <i>Giardia<\/i>-infected school children participated in this study. Vitamin A liver stores were evaluated with the modified relative dose response (MRDR) technique, and antiparasitic treatment was administered. In addition, anthropometric and dietary data were collected. <i>Results:<\/i> According to anthropometric indicators (age-appropriate Z scores for weight, height and body mass index) and daily vitamin A intake, the children had a normal nutritional status. Although the mean serum retinol levels did not change significantly after treatment for <i>Giardia<\/i> (p > 0.05), the MRDR values showed significant improvement (p < 0.002). <i>Conclusion:<\/i> Giardiasis not only compromises the vitamin A status through intestinal malabsorption, it also causes profound mobilization of liver retinol stores.<\/jats:p>","DOI":"10.1159\/000321682","type":"journal-article","created":{"date-parts":[[2010,12,14]],"date-time":"2010-12-14T13:20:39Z","timestamp":1292332839000},"page":"228-233","source":"Crossref","is-referenced-by-count":27,"title":["<i>Giardia lamblia <\/i>Infection and Its Implications for Vitamin A Liver Stores in School Children"],"prefix":"10.1159","volume":"57","author":[{"given":"Humberto","family":"Astiazaran-Garcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Lopez-Teros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro E.","family":"Valencia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Vazquez-Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norberto","family":"Sotelo-Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Quihui-Cota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,12,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1128%2FCMR.14.1.150-164.2001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0035-9203%2893%2990531-T"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1006%2Fexpr.2000.4514"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0020-7519%2801%2900340-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1024%2F0300-9831.78.2.51"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0035-9203%2890%2990386-S"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Ftropej%2F44.4.248"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1590%2FS0037-86822002000200002"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0169-4758%2890%2990145-T"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1128%2FIAI.68.6.3412-3418.2000"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1079%2FBJN2002599"}],"container-title":["Annals of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/321682","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/321682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:02:31Z","timestamp":1745434951000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000321682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":11,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2011,1,1]]},"published-print":{"date-parts":[[2011,1,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000321682","archive":["Portico"],"relation":{},"ISSN":["0250-6807","1421-9697"],"issn-type":[{"value":"0250-6807","type":"print"},{"value":"1421-9697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}