{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:27:05Z","timestamp":1790177225990,"version":"4.1.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,11,17]],"date-time":"2010-11-17T00:00:00Z","timestamp":1289952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,11,17]],"date-time":"2010-11-17T00:00:00Z","timestamp":1289952000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroepidemiology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Updated, robust estimates of the incidence and prevalence of rare long-term neurological conditions in the UK are not available. Global estimates may be misrepresentative as disease aetiology may vary by location. &lt;i&gt;Objectives:&lt;\/i&gt; To systematically review the incidence and prevalence of long-term neurological conditions in the UK since 1988. &lt;i&gt;Search Strategy:&lt;\/i&gt; Medline (January 1988 to January 2009), Embase (January 1988 to January 2009), CINAHL (January 1988 to January 2009) and Cochrane CENTRAL databases. &lt;i&gt;Selection Criteria:&lt;\/i&gt; UK population-based incidence\/prevalence studies of long-term neurological conditions since 1988. Exclusion criteria included inappropriate diagnoses and incomprehensive case ascertainment. &lt;i&gt;Data Collection and Analysis:&lt;\/i&gt; Articles were included based on the selection criteria. Data were extracted from articles with ranges of incidence and prevalence reported. &lt;i&gt;Main Results:&lt;\/i&gt; Eight studies met the criteria (3 on motor neurone disease; 4 on Huntington\u2019s disease; 1 on progressive supranuclear palsy). The incidence of motor neurone disease ranged from 1.06 to 2.4\/100,000 person-years. The prevalence ranged from 4.02 to 4.91\/100,000. The prevalence of Huntington\u2019s disease ranged from 4.0 to 9.94\/100,000. The prevalence of progressive supranuclear palsy ranged from 3.1 to 6.5\/100,000. &lt;i&gt;Conclusions:&lt;\/i&gt; The review updates the incidence\/prevalence of long-term neurological conditions. Future epidemiological studies must incorporate comprehensive case ascertainment methods and strict diagnostic criteria.<\/jats:p>","DOI":"10.1159\/000321712","type":"journal-article","created":{"date-parts":[[2010,11,17]],"date-time":"2010-11-17T07:42:08Z","timestamp":1289979728000},"page":"19-28","source":"Crossref","is-referenced-by-count":33,"title":["A Systematic Review of the Incidence and Prevalence of Long-Term Neurological Conditions in the UK"],"prefix":"10.1159","volume":"36","author":[{"given":"Thomas","family":"Hoppitt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hardev","family":"Pall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mel","family":"Calvert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paramjit","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqing","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Ramsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gill","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacky","family":"Conduit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cath","family":"Sackley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,11,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000108917"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00415-006-0454-y"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00415-006-0195-y"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.65.6.842"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.32.7.524"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Fageing%2F23.6.445"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F124.7.1438"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jns.2005.08.009"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.20110"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2899%2904137-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1192%2Fbjp.155.6.799"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2F8.2.157"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jns.2008.09.024"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00313868"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F118.3.707"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.870130305"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-0004.1974.tb00638.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000261912.53959.b4"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2Fmus.10327"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2806%2970447-1"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-1331.2006.01552.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-510X%2894%2990191-0"}],"container-title":["Neuroepidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/321712","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/321712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:03:07Z","timestamp":1745434987000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000321712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,17]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,2,1]]},"published-print":{"date-parts":[[2011,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000321712","archive":["Portico"],"relation":{},"ISSN":["0251-5350","1423-0208"],"issn-type":[{"value":"0251-5350","type":"print"},{"value":"1423-0208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,17]]}}}