{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:20:27Z","timestamp":1791188427458,"version":"4.1.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,11,25]],"date-time":"2010-11-25T00:00:00Z","timestamp":1290643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,11,25]],"date-time":"2010-11-25T00:00:00Z","timestamp":1290643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Antibiotics have been shown to improve hidradenitis suppurativa (HS) patients but complete remission is rare using these treatments. &lt;i&gt;Objective:&lt;\/i&gt; To assess the efficacy and safety of a combination of oral rifampin, moxifloxacin and metronidazole in long-lasting refractory HS. &lt;i&gt;Methods:&lt;\/i&gt; We retrospectively studied 28 consecutive HS patients including 6, 10 and 12 Hurley stage 1, 2 and 3 patients, respectively. Complete remission, defined as a clearance of all inflammatory lesions including hypertrophic scars, was the main outcome criterion of the study. &lt;i&gt;Results:&lt;\/i&gt; Complete remission was obtained in 16 patients, including 6\/6, 8\/10 and 2\/12 patients with Hurley stage 1, 2 and 3, respectively (p = 0.0004). The median duration of treatment to obtain complete remission was 2.4 (range 0.9\u20136.5) and 3.8 months (range 1.6\u20137.4) in stage 1 and 2 patients, respectively, and 6.2 and 12 months in the 2 stage 3 patients. Main adverse events of the treatments were gastrointestinal disorders (64% of patients) and vaginal candidiasis (35% of females). Reversible tendinopathy and hepatitis occurred in 4 and 1 patient, respectively. &lt;i&gt;Conclusions:&lt;\/i&gt; Complete remission of refractory HS can be obtained using broad-spectrum antibiotics and Hurley staging is a prognostic factor of response to the treatment.<\/jats:p>","DOI":"10.1159\/000321716","type":"journal-article","created":{"date-parts":[[2010,11,25]],"date-time":"2010-11-25T07:59:33Z","timestamp":1290671973000},"page":"49-58","source":"Crossref","is-referenced-by-count":135,"title":["Efficacy of Rifampin-Moxifloxacin-Metronidazole Combination Therapy in Hidradenitis 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