{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:36:09Z","timestamp":1745469369007,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Ethyl chloride (EC) is usually used as a topical anesthetic spray agent. However, its antipruritic effects have never been studied, to the best of our knowledge. &lt;i&gt;Methods:&lt;\/i&gt; A double-blind placebo-controlled prospective study. Overall, 51 healthy volunteers underwent a histamine skin prick test on both arms in order to trigger local pruritus. Thereafter, the affected areas were treated with an EC spray on one arm and a saline spray (placebo) on the other. Subjects as well as researchers were blind to which sprays were used. Subjects reported improvement in pruritus following EC\/placebo and rated the intensity of pruritus by using a validated questionnaire and a visual analog scale. The flare and wheal reactions were measured in both arms before and following treatment with EC\/placebo. &lt;i&gt;Results:&lt;\/i&gt; Significant improvement in pruritus was reported more frequently following treatment with EC compared with placebo (84 vs. 16%; p &lt; 0.0001). Significant reduction in pruritus intensity was reported immediately and 15 min following treatment with EC compared with placebo (p &lt; 0.05). There was no significant difference between EC and placebo in terms of the flare and wheal reactions. &lt;i&gt;Conclusions:&lt;\/i&gt; EC is an effective antipruritic agent, and it does not change the wheal and flare reactions, making it ideal for treating pruritus secondary to allergy skin tests without masking their results.<\/jats:p>","DOI":"10.1159\/000321720","type":"journal-article","created":{"date-parts":[[2010,11,22]],"date-time":"2010-11-22T08:20:24Z","timestamp":1290414024000},"page":"373-377","source":"Crossref","is-referenced-by-count":5,"title":["Ethyl Chloride as an Antipruritic Agent: A Double-Blind Placebo-Controlled Prospective Study"],"prefix":"10.1159","volume":"221","author":[{"given":"Amir","family":"Gal-Oz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ori","family":"Rogowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Swartzon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shmuel","family":"Kivity","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,11,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0166-2236%2892%2990102-E"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2803%2912570-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1988.tb03259.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS1081-1206%2810%2961204-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080%2F00015550152384236"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2896%2904328-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2896%2904176-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F01.pec.0000278396.25129.3f"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2899%2900257-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0923-1811%2801%2900167-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0079-6123%2800%2929021-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11882-008-0049-z"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2899%2900257-8"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/321720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/321720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:03:15Z","timestamp":1745434995000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000321720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,12,1]]},"published-print":{"date-parts":[[2010,12,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000321720","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2010]]}}}