{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:20:26Z","timestamp":1761895226941,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>We retrospectively compared the clinicopathological features of primary intestinal follicular lymphomas (FL-GIs), nodal follicular lymphomas (FL-LNs) and gastrointestinal MALT lymphomas (MALT-GIs), and investigated the distribution and the endoscopic appearances of FL-GI to evaluate the effectiveness of treatment modality. The subjects were 28 FL-GI patients, 135 FL-LN patients and 70 MALT-GI patients. In FL-LNs the clinical stage III\u2013IV was 83%, while in FL-GIs clinical stage I\u2013II was 68%. In MALT-GIs clinical stage I\u2013II was 87%. The overall survival was significantly better in MALT-GI patients than in FL-LN patients. All FL-GI patients were alive at the time of evaluation. Regarding the histological grade (WHO), grade 1 was 81% in FL-GI, whereas in FL-LN grade 2 was 28% and grade 3 was 11%. The Follicular Lymphoma International Prognostic Index was low in 61% of FL-GIs, while in FL-LNs it was equally distributed to low, intermediate and high, suggesting that the prognosis is better in FL-GIs than in FL-LNs. The clinicopathological studies revealed the FL-GI has intermediate characteristics between FL-LN and MALT-GI. We recommend a \u2018watch-and-wait\u2019 policy or chemotherapy with rituximab for the therapy of FL-GIs because the lesions are often located in broader areas from the lower duodenum to the small intestine.<\/jats:p>","DOI":"10.1159\/000321814","type":"journal-article","created":{"date-parts":[[2011,1,24]],"date-time":"2011-01-24T07:52:14Z","timestamp":1295855534000},"page":"191-197","source":"Crossref","is-referenced-by-count":15,"title":["Clinical Features of Gastrointestinal Follicular Lymphoma: Comparison with Nodal Follicular Lymphoma and Gastrointestinal MALT Lymphoma"],"prefix":"10.1159","volume":"83","author":[{"given":"Akira","family":"Tari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Asaoku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Kunihiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumu","family":"Fujihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2003-12-4434"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00004836-200209000-00020"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00000478-200202000-00008"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00277-002-0436-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fgcc.10013"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00535-003-1096-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2559.2004.01804.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1067%2Fmge.2001.114963"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fjcp.2007.049825"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS1542-3565%2804%2900453-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2007-995365"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2F00000421-198212000-00014"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1203018"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2Fmodpathol.3880393"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038%2Fmodpathol.2009.51"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00795-009-0477-4"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/321814","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/dig\/article-pdf\/83\/3\/191\/4034288\/000321814.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/dig\/article-pdf\/83\/3\/191\/4034288\/000321814.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:04:05Z","timestamp":1745435045000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000321814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,1,1]]},"published-print":{"date-parts":[[2011,1,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000321814","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"type":"print","value":"0012-2823"},{"type":"electronic","value":"1421-9867"}],"subject":[],"published":{"date-parts":[[2011]]}}}