{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:21:14Z","timestamp":1761016874744,"version":"3.40.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Neurosurg"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To evaluate the surgical outcome for intractable, MRI-negative infantile spasms (IS), and to identify diagnostic targets in the focal epileptogenic area by methods other than MRI. &lt;i&gt;Methods:&lt;\/i&gt; We retrospectively studied 9 patients who had had surgery for intractable IS, and whose lesions did not appear on MRI. We analyzed video\/electroencephalography (EEG), single photon emission computed tomography (SPECT) and positron emission tomography (PET) findings and their surgical outcomes. In 7 patients who were seizure free after surgery, we analyzed the EEG parameters for characteristics expected in the primary epileptogenic region. &lt;i&gt;Results:&lt;\/i&gt; All patients underwent resective surgery including frontal lobectomy and multilobar resection. Seven patients showed an Engel class I outcome, and 2 patients showed a class III outcome. Interictal SPECT results showed 66.7% concordance for the hemisphere affected (lateralization), and 55.6% for lesion location (localization). Ictal SPECT showed 71.4% concordance for lateralization and localization. PET showed 66.7% concordance for lateralization, and 55.6% for localization. EEG parameters, including localized paroxysmal fast activities, spindle-shaped fast activities, repetitive or rhythmic sharp\/spike wave discharges, and subclinical seizures showed highly localized specificity, and may serve to identify the epileptogenic lesion. &lt;i&gt;Conclusion:&lt;\/i&gt; Surgical treatment of MRI-negative IS should be justified using a combination of diagnostic methods.<\/jats:p>","DOI":"10.1159\/000321925","type":"journal-article","created":{"date-parts":[[2010,10,21]],"date-time":"2010-10-21T06:55:38Z","timestamp":1287644138000},"page":"182-187","source":"Crossref","is-referenced-by-count":11,"title":["Electroencephalography Features of Primary Epileptogenic Regions in Surgically Treated MRI-Negative Infantile Spasms"],"prefix":"10.1159","volume":"46","author":[{"given":"Yun Jung","family":"Hur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Soo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Seok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taegyu","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heung Dong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,10,21]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1016%2FS0887-8994%2800%2900238-1"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1016%2FS0887-8994%2897%2900013-1"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1016%2FS0387-7604%2801%2900305-9"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1136%2Fjnnp.34.4.369"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1016%2FS0387-7604%2801%2900204-2"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1111%2Fj.1528-1167.2005.00340.x"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1159%2F000089505"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.3345%2Fkjp.2009.52.7.804"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1111%2Fj.1528-1157.1993.tb00459.x"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1111%2Fj.0013-9580.2004.05003.x"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1136%2Fjnnp.2003.026757"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1002%2Fana.410270408"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1111%2Fj.1528-1157.1993.tb00450.x"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1111%2Fj.1528-1157.1994.tb02543.x"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1016%2Fj.pediatrneurol.2004.01.008"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1111%2Fj.0013-9580.2004.t01-1-04004.x"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1097%2F00004691-199611000-00004"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1016%2FS0920-1211%2802%2900102-X"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.1111%2Fj.1528-1167.2007.01428.x"},{"doi-asserted-by":"publisher","key":"ref20","DOI":"10.1111%2Fj.1528-1157.1996.tb00626.x"},{"doi-asserted-by":"publisher","key":"ref21","DOI":"10.1111%2Fj.1469-8749.1997.tb07462.x"},{"doi-asserted-by":"publisher","key":"ref22","DOI":"10.1016%2Fj.braindev.2005.11.011"}],"container-title":["Pediatric Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/321925","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/321925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:05:30Z","timestamp":1745435130000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000321925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,11,1]]},"published-print":{"date-parts":[[2010,11,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000321925","archive":["Portico"],"relation":{},"ISSN":["1016-2291","1423-0305"],"issn-type":[{"type":"print","value":"1016-2291"},{"type":"electronic","value":"1423-0305"}],"subject":[],"published":{"date-parts":[[2010]]}}}