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Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,11,27]],"date-time":"2010-11-27T00:00:00Z","timestamp":1290816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,11,27]],"date-time":"2010-11-27T00:00:00Z","timestamp":1290816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Aims:&lt;\/i&gt; Our objectives were to assess inherited thrombophilia and non-O blood group for the risk of gestational vascular complications among the Tunisian population. &lt;i&gt;Methods:&lt;\/i&gt; This study comprised 203 test subjects with adverse pregnancy outcomes including recurrent pregnancy loss, intra-uterine growth retardation, pre-eclampsia and placental abruption. Each subgroup was matched with 100 controls and analyzed separately. All patients were evaluated for factor V Leiden, factor II G20210A mutations and for non-O blood group. Protein S, protein C and antithrombin levels were determined and deficiencies noted. &lt;i&gt;Results:&lt;\/i&gt; The factor V Leiden mutation, non-O blood group and protein C deficiency had the highest incidences among patients both as a whole and in the 4 subgroups. The factor II G20210A mutation, protein S and antithrombin deficiencies were not statistically significant risk factors. &lt;i&gt;Conclusion:&lt;\/i&gt; Our results provide evidence for a significant association between the factor V mutation and placental abruption. Furthermore, we found that this and the non-O blood group independently increased the risk for intra-uterine growth retardation in our population.<\/jats:p>","DOI":"10.1159\/000321934","type":"journal-article","created":{"date-parts":[[2010,11,29]],"date-time":"2010-11-29T07:41:33Z","timestamp":1291016493000},"page":"115-120","source":"Crossref","is-referenced-by-count":8,"title":["The Status of Thrombophilic Defects and Non-O Blood Group as Risk Factors for Gestational Vascular Complications among Tunisian 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