{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:36:21Z","timestamp":1745469381350,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Background\/Aims: Our aim was to determine how weight change influences the development of advanced adenomas. Methods: We performed a retrospective study of patients with adenomatous polyps (APs) on an index colonoscopy, and who also had a follow-up colonoscopy 3\u20135 years later. APs were evaluated for advanced features (i.e. size \u22671 cm in diameter and\/or villous component and\/or high-grade dysplasia). Patients were divided into 2 groups: those with no change or a reduction in their body mass index (BMI) during the interval between colonoscopies and those with an increase in BMI during the interval between colonoscopies. Results: 925 patients with a history of APs were identified. Univariate analysis showed that patients with an increase in BMI had more advanced APs (28 vs. 23%, p = 0.04), and a larger mean AP size (8.0 vs. 6.8 mm, p = 0.03) than those with a no change or decreased BMI. Multiple logistic regression analysis revealed that a decrease in BMI between colonoscopies was associated with a significantly reduced risk of developing advanced APs (OR: 0.4, 95% CI: 0.37\u20130.5, p &lt; 0.05). Conclusions: An increase in weight in male veterans appears to be strongly associated with the development of clinically advanced AP lesions, even after adjustment for other known polyp risk factors.<\/jats:p>","DOI":"10.1159\/000322042","type":"journal-article","created":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T13:05:53Z","timestamp":1296479153000},"page":"288-290","source":"Crossref","is-referenced-by-count":3,"title":["Increase in Body Size Is Associated with an Increased Incidence of Advanced Adenomatous Colon Polyps in Male Veteran Patients"],"prefix":"10.1159","volume":"83","author":[{"given":"Ali","family":"Siddiqui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mimi","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amar","family":"Mahgoub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene N. Pena","family":"Sahdala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,2,1]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.3322%2Fcaac.20006"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1007%2FBF01649506"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1080%2F003655299750026443"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1056%2FNEJM199203053261002"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1007%2FBF00051301"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1207%2FS15327914nc391_7"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1007%2Fs00535-007-2074-4"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1158%2F1055-9965.EPI-04-0757"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1056%2FNEJM199312303292701"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1093%2Fjnci%2F83.5.359"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1007%2Fs00535-007-2074-4"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1016%2Fj.cgh.2007.03.022"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1007%2Fs10620-009-0811-7"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1046%2Fj.1365-2168.2001.01645.x"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1016%2FS0140-6736%2804%2916044-3"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1158%2F1055-9965.EPI-06-0229"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/322042","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/dig\/article-pdf\/83\/4\/288\/4034308\/000322042.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/dig\/article-pdf\/83\/4\/288\/4034308\/000322042.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:06:49Z","timestamp":1745435209000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000322042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,4,1]]},"published-print":{"date-parts":[[2011,4,18]]}},"URL":"https:\/\/doi.org\/10.1159\/000322042","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"type":"print","value":"0012-2823"},{"type":"electronic","value":"1421-9867"}],"subject":[],"published":{"date-parts":[[2011]]}}}