{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:22:30Z","timestamp":1790857350069,"version":"4.1.0"},"reference-count":35,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Human papillomaviruses (HPVs) have been linked to a variety of human diseases, most notably cancer of the cervix. In the majority of cases, HPV proteins E6 and E7 are continuously expressed and bind a variety of cellular proteins. The precise mechanism of HPV-induced carcinogenesis has not been fully elucidated; therefore, we attempted to identify the cellular proteins that interact with HPV18 E7 to better understand the function of this important protein. Using yeast 2-hybrid screening, we identified centromere protein C (CENP-C) as one of the proteins that interact with HPV18 E7. CENP-C interacted with E7 from HPV18 but not from HPV11. The CR2 domain of HPV18 E7 and the C-terminal region of CENP-C were found to be involved in the binding of these proteins. CENP-C is a component of the inner kinetochore and plays an essential role in proper chromosome segregation, mitotic checkpoint function, and kinetochore assembly. HPV18 E7\u2013CENP-C binding may therefore impair centromere function, in turn causing cancers. We speculate that altered function of CENP-C as a result of interactions with HPV E7 may be associated with chromosomal abnormalities in HPV18-positive cancers.<\/jats:p>","DOI":"10.1159\/000322188","type":"journal-article","created":{"date-parts":[[2011,3,3]],"date-time":"2011-03-03T08:36:37Z","timestamp":1299141397000},"page":"219-228","source":"Crossref","is-referenced-by-count":6,"title":["Characterization of Physical Binding between Human Papillomavirus 18 Protein E7 and Centromere Protein C"],"prefix":"10.1159","volume":"79","author":[{"given":"Yuji","family":"Yaginuma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinya","family":"Yoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiro","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,3,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0738-081X%2896%2900164-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3322%2Fcanjclin.55.2.74"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-9896%28199909%29189%3A1%3C12%3A%3AAID-PATH431%3E3.0.CO%3B2-F"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1323879"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2F92.9.690"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1128%2FJVI.78.21.11451-11460.2004"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038%2Fnrc798"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2Fs12094-007-0066-8"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fjcb.21609"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1101%2Fgad.12.15.2245"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2807%2961416-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fpath.1866"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1128%2FJVI.77.22.12331-12335.2003"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ccr.2006.10.019"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ccr.2006.12.006"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.canlet.2004.12.028"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0959-437X%2800%2900161-1"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.95.3.1136"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cell.2006.11.042"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1128%2FMCB.22.7.2229-2241.2002"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.2537532"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1006%2Fviro.1998.9220"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2892%2990538-N"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093%2Femboj%2F18.15.4196"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2F6.13.2301"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1091%2Fmbc.E07-01-0045"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007%2Fs100670050029"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1136%2Fard.62.8.728"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1136%2Fjcp.51.2.96"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.89.10.4442"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1208589"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1210633"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.200303167"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1158%2F0008-5472.CAN-07-2266"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ccr.2006.12.003"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/322188","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/322188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/322188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:08:19Z","timestamp":1745435299000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000322188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":35,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2011,3,1]]},"published-print":{"date-parts":[[2011,3,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000322188","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}