{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:25:53Z","timestamp":1773923153470,"version":"3.50.1"},"reference-count":22,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T00:00:00Z","timestamp":1293062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T00:00:00Z","timestamp":1293062400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; FSH-secreting pituitary adenomas are extremely rare in children and are seldom associated with clinical manifestations of high serum gonadotrophin levels. Thus, most patients have a late presentation, usually as macroadenomas. &lt;i&gt;Case Reports:&lt;\/i&gt; Two different clinical forms of presentation of FSH-secreting pituitary adenomas are reported: one in a 12-year-old boy with macroorchidism due to a pituitary microadenoma, probably FSH-secreting, and the other in a 15-year-old boy with panhypopituitarism due to an FSH-producing macroadenoma. Both patients presented slightly high or high FSH with low LH and high inhibin B levels. In the first case, the microadenoma was treated medically with cabergoline, which failed to reduce FSH and inhibin B levels. No radiological progression has been observed despite increasing testicular volume. In the second case, surgery was performed on the macroadenoma, leading to a decrease in FSH and inhibin B levels. The patient developed severe hypothalamic obesity and is currently under treatment with somatostatin. &lt;i&gt;Conclusions:&lt;\/i&gt; FSH-secreting pituitary tumors have an extremely variable clinical expression. The discrepancy between normal or slightly increased FSH and low LH values, together with high inhibin B levels, strongly suggests FSH hypersecretion which should be studied.<\/jats:p>","DOI":"10.1159\/000322211","type":"journal-article","created":{"date-parts":[[2011,1,3]],"date-time":"2011-01-03T09:47:56Z","timestamp":1294048076000},"page":"225-230","source":"Crossref","is-referenced-by-count":22,"title":["Macroorchidism and Panhypopituitarism: Two Different Forms of Presentation of FSH-Secreting Pituitary Adenomas in Adolescence"],"prefix":"10.1159","volume":"75","author":[{"given":"Mar\u00eda","family":"Clemente","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiola","family":"Caracseghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miquel","family":"Gussinyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Yeste","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian","family":"Albisu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elida","family":"V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arantxa","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Carrascosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,12,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.84.12.4317"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.84.12.4385"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00006123-199804000-00037"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02724183"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.1.01854"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.1989.tb01265.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.82.12.3976"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1157%2F13123287"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-1569"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0015-0282%2899%2900197-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs007950000004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000284395"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4065%2F71.7.649"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3171%2Ffoc.2004.16.4.8"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.8.3635"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F01.AOG.0000141554.50747.16"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038%2Fncpendmet0758"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fdem374"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.1993.tb01010.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11102-008-0124-4"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2002-030003"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2165%2F00003495-200868140-00003"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/322211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/322211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:08:33Z","timestamp":1745435313000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000322211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,23]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,3,1]]},"published-print":{"date-parts":[[2011,3,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000322211","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,23]]}}}