{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:53:48Z","timestamp":1779933228729,"version":"3.53.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Objective:<\/i> To describe the contribution of 3-dimensional computed tomography (3D-CT) in the prenatal diagnosis of skeletal dysplasias (SD) in a cohort of patients with inconclusive diagnosis by ultrasound (US). <i>Methods:<\/i> Between May 2007 and February 2010, six pregnant women with suspected fetal SD on US examination but with no specific diagnosis were studied with 3D-CT. The images were evaluated by a multidisciplinary team who proposed a likely diagnosis. Further postnatal workup included clinical and radiological evaluation in all cases. Prenatal and postnatal diagnoses were compared. <i>Results:<\/i> The use of 3D-CT provided a precise diagnosis confirmed postnatally in 5\/6 patients. These included osteogenesis imperfecta type II (n = 2), osteogenesis imperfecta type III (n = 1), chondrodysplasia punctata (n = 1) and thanatophoric dysplasia type I (n = 1). A precise diagnosis could not be made in 1 case \u2013 either pre- or postnatally. <i>Conclusion:<\/i> Prenatal 3D-CT contributed to the diagnosis of the specific fetal SD in the majority of these cases. 3D-CT may have a complementary role to US where fetal SD is suspected, but no specific diagnosis can be made using US alone. Further studies on clinical performance and risk-benefit analysis are needed.<\/jats:p>","DOI":"10.1159\/000322212","type":"journal-article","created":{"date-parts":[[2011,4,13]],"date-time":"2011-04-13T13:32:14Z","timestamp":1302701534000},"page":"238-247","source":"Crossref","is-referenced-by-count":31,"title":["Prenatal Diagnosis of Skeletal Dysplasias: Contribution of Three-Dimensional Computed Tomography"],"prefix":"10.1159","volume":"29","author":[{"given":"Marina","family":"Ulla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio","family":"Aiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Paz","family":"Cobos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00eada","family":"Orioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Garc\u00eda-M\u00f3naco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Etchegaray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Laura","family":"Igarz\u00e1bal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Ota\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,1,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-0004.1989.tb02912.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.23.4.328"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fuog.1113"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fuog.4001"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1896"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1148%2Frg.284075122"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-8628%2819960102%2961%3A1%3C49%3A%3AAID-AJMG10%3E3.0.CO%3B2-W"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0223%28199804%2918%3A4%3C357%3A%3AAID-PD276%3E3.0.CO%3B2-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-8628%2819980217%2975%3A5%3C518%3A%3AAID-AJMG12%3E3.0.CO%3B2-N"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1515%2FJPM.2002.006"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fuog.111"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.0960-7692.2001.00521.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00247-010-1598-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.0960-7692.2001.00496.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra072149"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093%2Frpd%2Fncm246"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0705.2001.00523.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2004-812946"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejrad.2005.11.017"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00330-007-0604-3"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/322212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/322212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:08:33Z","timestamp":1745435313000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000322212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,4,1]]},"published-print":{"date-parts":[[2011,4,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000322212","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}