{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:36:32Z","timestamp":1745469392870,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Introduction:<\/i> There is a paucity of data investigating the relationship between histopathological variables of oncologic importance and prostate volume, and we aimed to investigate this. <i>Patients and Methods:<\/i> 2,207 consecutive patients who underwent robotic-assisted radical prostatectomy were studied. Preoperative demographic and both pre- and postoperative histopathological parameters were compared among the small (<40 cm<sup>3<\/sup>), intermediate (40\u201370 cm<sup>3<\/sup>), and large (>70 cm<sup>3<\/sup>) prostate groups. <i>Results:<\/i> Patients with smaller prostates were younger, had slightly lower BMIs, and lower prostate-specific antigen (PSA) levels than those with larger prostates (p < 0.001). They also had worse histopathological criteria (Gleason, core positivity, and maximum percent cancer) on preoperative biopsy and had worse radical specimen Gleason sums (p < 0.001), percent cancer (p < 0.001), and pathological stage (p = 0.016). 11.5% of the men in the small prostate group suffered a positive surgical margin (PSM) compared to 8.3 and 5.6% in the intermediate and large prostate groups, respectively (p = 0.008). Basilar, posterolateral, and multifocal PSMs were commoner in the small prostate group. <i>Conclusions:<\/i> Younger men have smaller prostates and worse preoperative histopathological parameters despite lower PSA values. Men with small prostates undergoing robotic-assisted radical prostatectomy have worse final Gleason sums, tumour volume, extraprostatic extension, and PSM rates than those with larger prostates.<\/jats:p>","DOI":"10.1159\/000322361","type":"journal-article","created":{"date-parts":[[2011,3,18]],"date-time":"2011-03-18T08:39:56Z","timestamp":1300437596000},"page":"152-155","source":"Crossref","is-referenced-by-count":7,"title":["Prostate Volume and Its Correlation with Histopathological Outcomes in Prostate Cancer"],"prefix":"10.1159","volume":"86","author":[{"given":"Prasanna","family":"Sooriakumaran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhristie","family":"Bhagat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majnu","family":"John","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonal","family":"Grover","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youssef","family":"El-Douaihy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sivaram","family":"Rajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashutosh","family":"Tewari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,1,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322%2Fcanjclin.56.2.106"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2005.06.001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2801%2966792-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-410X.2010.09406.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-410X.2009.08688.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2007.10.017"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.urology.2005.06.108"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.juro.2009.11.046"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-410X.2009.08953.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2820000915%2989%3A6%3C1308%3A%3AAID-CNCR16%3E3.0.CO%3B2-3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.juro.2010.03.039"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1089%2Fend.2008.0247"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2898%2900228-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1464-410X.2003.04361.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-410X.2009.09182.x"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/322361","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/322361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:10:51Z","timestamp":1745435451000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000322361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,3,1]]},"published-print":{"date-parts":[[2011,3,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000322361","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2011]]}}}