{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T15:34:15Z","timestamp":1769096055916,"version":"3.49.0"},"reference-count":4,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2011,6,29]],"date-time":"2011-06-29T00:00:00Z","timestamp":1309305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,6,29]],"date-time":"2011-06-29T00:00:00Z","timestamp":1309305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2012]]},"abstract":"<i>Purpose:<\/i> To evaluate resistances mediated by extended-spectrum \u03b2-lactamases (ESBLs) and <i>AmpC <\/i>\u03b2-lactamases among Gram-negative bacteria recovered from ocular infections. <i>Methods:<\/i> As per the Clinical Laboratory Standards Institute M100-S-16 document, a total of 135 Gram-negative bacilli were recovered from ocular specimens and were subjected to phenotypic confirmation for ESBL production by the double-disc synergy test, cephalosporin and clavulanate combination disc test and E test, and, for <i>AmpC<\/i> \u03b2-lactamase, the modified double-disc approximation method and <i>AmpC <\/i>disc test. <i>Results:<\/i> In the double-disc synergy test, 21 (15.5%) isolates showed positive results against the cefpodoxime disc, 19 (14%) against cefpodoxime and cefotaxime, 15 (11%) against cefpodoxime, cefotaxime and ceftriaxone and 10 (7%) isolates were against cefpodoxime, cefotaxime, ceftriaxone and ceftazidime discs. In the cephalosporin\/clavulanate combination disc test, 19 (14%) isolates showed positive results against cefotaxime with clavulanic acid and 10 (7%) isolates against ceftazidime with clavulanic acid. In the E test, 10 (7%) isolates displayed positive results against ceftazidime and 19 (14%) against cefotaxime. In the <i>AmpC<\/i> disc test for phenotypic confirmation, indentations were observed in 15 (11%) isolates with flattening also occurring in 10 (7%) isolates. <i>Conclusion:<\/i> The incidences of ESBL- and <i>AmpC<\/i> \u03b2-lactamase-mediated resistances are found to be 7 and 18.5% among ocular isolates, respectively, and are more prevalent among the strains of <i>Escherichia coli<\/i> and <i>Klebsiella pneumoniae<\/i>.<\/jats:p>","DOI":"10.1159\/000322807","type":"journal-article","created":{"date-parts":[[2011,6,29]],"date-time":"2011-06-29T09:53:51Z","timestamp":1309341231000},"page":"52-56","source":"Crossref","is-referenced-by-count":11,"title":["Extended-Spectrum Beta-Lactamase-Mediated Resistance among Bacterial Isolates Recovered from Ocular Infections"],"prefix":"10.1159","volume":"47","author":[{"given":"M.","family":"Jayahar Bharathi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ramakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ramesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Murugan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,6,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1128%2FCMR.18.4.657-686.2005"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4103%2F0255-0857.16053"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.48.1.1-14.2004"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0924-8579%2802%2900210-8"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/322807","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/322807","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/322807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:14:55Z","timestamp":1745435695000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000322807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,29]]},"references-count":4,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,12,1]]},"published-print":{"date-parts":[[2011,12,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000322807","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,29]]}}}