{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:36:46Z","timestamp":1745469406978,"version":"3.40.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytogenet Genome Res"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Chronic myeloid leukemia (CML) is a clonal malignant disorder of a pluripotent hematopoietic stem cell characterized by the presence of a Philadelphia (Ph) chromosome. Less than 10% of patients present variant Ph chromosomes involving 1 or more additional chromosomes, other than chromosomes 9 and 22, with uncertain prognosis. There are mainly 1- or 2-step mechanisms proposed to explain the genesis of variant Ph chromosomes depending on whether the involved chromosomes are simultaneously broken and rejoined or if a standard t(9;22) occurs first. By combined standard cytogenetic and FISH analysis we detected a novel variant Ph translocation among chromosomes 9, 11 and 22 in a patient with CML without progression to an accelerated phase of the disease after 7 years, with the derivative chromosome 9 also having an acquired pericentric inversion. This novel case illustrates the use of FISH in metaphase to confirm a new rearrangement not previously described in variant Ph formation and that the present karyotype could have originated by a 1-step mechanism with 4 simultaneous breakages without deletion of &lt;i&gt;ABL1&lt;\/i&gt;.<\/jats:p>","DOI":"10.1159\/000322824","type":"journal-article","created":{"date-parts":[[2011,2,4]],"date-time":"2011-02-04T07:44:23Z","timestamp":1296805463000},"page":"304-308","source":"Crossref","is-referenced-by-count":3,"title":["Novel Variant Ph Translocation t(9;22;11)(q34;q11.2;p15)inv(9)(p13q34) in Chronic Myeloid Leukemia Involving a One-Step Mechanism"],"prefix":"10.1159","volume":"132","author":[{"given":"C.","family":"Belli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.F.","family":"Al\u00fa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Alfonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bianchini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Larripa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,1,6]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1182%2Fblood-2006-02-005686"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1016%2Fj.cancergencyto.2009.05.010"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1126%2Fscience.2406902"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1111%2Fj.1365-2141.2004.04899.x"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1016%2Fj.cancergencyto.2006.10.006"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1182%2Fblood-2006-09-047266"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1002%2Fgcc.10056"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1016%2FS0165-4608%2803%2900128-6"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1046%2Fj.1365-2141.2003.04291.x"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1016%2Fj.cancergencyto.2008.01.005"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.3324%2Fhaematol.2009.011452"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1016%2F0165-4608%2886%2990068-3"}],"container-title":["Cytogenetic and Genome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/322824","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/322824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:15:10Z","timestamp":1745435710000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000322824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,2,1]]},"published-print":{"date-parts":[[2011,2,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000322824","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5121595","asserted-by":"subject"}]},"ISSN":["1424-8581","1424-859X"],"issn-type":[{"type":"print","value":"1424-8581"},{"type":"electronic","value":"1424-859X"}],"subject":[],"published":{"date-parts":[[2011]]}}}