{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:36:50Z","timestamp":1745469410245,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Background and Aims:<\/i> Hepatitis C virus (HCV) infection is a frequent complication among long-term dialysis patients. The aim of the present study was to evaluate the efficacy and side effects of pegylated interferon-\u03b1<sub>2a<\/sub> (PEG-IFN-\u03b1<sub>2a<\/sub>) treatment in hemodialysis patients. <i>Methods:<\/i> We retrospectively reviewed charts of 16 HCV-RNA-positive hemodialysis patients. <i>Results:<\/i> There were 11 male and 5 female patients treated with dialysis for 6\u201328 years. Twelve patients had HCV genotype 1b, 2 patients had 3a, and 1 patient had genotype 2a. Although only 10 out of 16 patients completed 48 weeks of treatment, early virological response and end-of-treatment virological response were achieved in 9 and 13 patients, respectively. Sustained virological response was recorded in 9 patients. The most common side effect was anemia. A flu-like syndrome was documented in 6, myalgia in 4, and arthralgia in 5 patients. Rectorrhagia, endocarditis and severe cough were recorded in 1 patient each. Nine patients received a renal transplant, and all 6 responders remained HCV-RNA-negative. <i>Conclusions:<\/i> PEG-IFN-\u03b1<sub>2a<\/sub> has limited efficacy in dialysis patients. A significant proportion of patients discontinued treatment because of side effects. Additional studies with long-term follow-up are needed to determine the optimal treatment of HCV infection in the dialysis population.<\/jats:p>","DOI":"10.1159\/000322922","type":"journal-article","created":{"date-parts":[[2011,1,5]],"date-time":"2011-01-05T08:40:28Z","timestamp":1294216828000},"page":"53-57","source":"Crossref","is-referenced-by-count":4,"title":["Pegylated Interferon for Treatment of Chronic Hepatitis C in Hemodialysis Patients in Croatia"],"prefix":"10.1159","volume":"34","author":[{"given":"Nikolina","family":"Basic-Jukic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijana","family":"Gulin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasna","family":"Slavicek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Coric-Martinovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bosiljka","family":"Iskra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjin","family":"Racki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milenka","family":"Sain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajko","family":"Ostoji\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Hrstic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragan","family":"Ljutic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Vucelic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petar","family":"Kes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,1,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000101918"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2036.2004.02290.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2897%2990345-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2003.07526.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2F82191"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature03153"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.1840010511"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2004.00649.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2898%2970027-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F01.tp.0000259725.96694.0a"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1998.00883.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.2007.133884"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3748%2Fwjg.14.255"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.transproceed.2009.06.140"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00535-009-0016-z"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080%2F08860220701813368"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2007.11.003"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2Fjmv.21542"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1432-2277.2008.00831.x"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/322922","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/322922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:15:50Z","timestamp":1745435750000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000322922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,1,1]]},"published-print":{"date-parts":[[2011,1,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000322922","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"type":"print","value":"1420-4096"},{"type":"electronic","value":"1423-0143"}],"subject":[],"published":{"date-parts":[[2011]]}}}