{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:11:34Z","timestamp":1790629894909,"version":"4.1.0"},"reference-count":13,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Background:<\/i> Home mechanical ventilation is usually started in hospital as arterial blood gas sampling is deemed necessary to monitor CO<sub>2<\/sub> and O<sub>2<\/sub> adequately during institution of ventilatory support. A non-invasive device to reliably measure CO<sub>2<\/sub> transcutaneously would alleviate the need for high care settings for measurement and open the possibility for home registration. <i>Objectives:<\/i> In this study we investigated whether the TOSCA\u00ae transcutaneous CO<sub>2<\/sub> (PtcCO<sub>2<\/sub>) measurements, performed continuously during the night, reliably reflect arterial CO<sub>2<\/sub> (PaCO<sub>2<\/sub>) measurements in adults with chronic respiratory failure. <i>Methods:<\/i> Paired measurements were taken in 15 patients hospitalised to evaluate their blood gas exchange. Outcomes were compared 30 min, 2, 4, 6 and 8 h after attaching the sensor to the earlobe. A maximum difference of 1.0 kPa and 95% limits of agreement (LOA) of 1 kPa between CO<sub>2<\/sub> pressure measurements, following the analysis by Bland and Altman, were determined as acceptable. <i>Results:<\/i> Mean PtcCO<sub>2<\/sub> was 0.4 kPa higher (LOA \u20130.48 to 1.27 kPa) than mean PaCO<sub>2<\/sub> after 30 min. These figures were 0.6 kPa higher (LOA \u20130.60 to 1.80 kPa) after 4 h, with a maximum of 0.72 kPa (LOA 0.35 to 1.79 kPa) after 8 h. The corresponding values for changes in PtcCO<sub>2<\/sub> versus PaCO<sub>2<\/sub> were not significant (ANOVA). <i>Conclusions:<\/i> PtcCO<sub>2<\/sub> measurement, using TOSCA, is a valid method showing an acceptable agreement with PaCO<sub>2<\/sub> during 8 h of continuous measurement. Therefore, this device can be used to monitor CO<sub>2<\/sub> adequately during chronic ventilatory support.<\/jats:p>","DOI":"10.1159\/000323074","type":"journal-article","created":{"date-parts":[[2011,1,17]],"date-time":"2011-01-17T07:57:05Z","timestamp":1295251025000},"page":"242-246","source":"Crossref","is-referenced-by-count":24,"title":["Validation of a Transcutaneous CO<sub>2<\/sub> Monitor in Adult Patients with Chronic Respiratory Failure"],"prefix":"10.1159","volume":"81","author":[{"given":"A.","family":"Hazenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.G.","family":"Zijlstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.A.M.","family":"Kerstjens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"Wijkstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,1,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.rmed.2005.04.015"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000235721"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000127410"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.07-1173"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053%2Frmed.2001.1045"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.2005.051664"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000187631"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1460-9592.2003.01146.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F01.CCM.0000181734.26070.26"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2044.2007.04987.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.128.3.1291"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1152%2Fclassicessays.00021.2004"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1460-9592.2009.02930.x"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:17:45Z","timestamp":1745435865000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000323074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,2,1]]},"published-print":{"date-parts":[[2011,2,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000323074","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}