{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:09:04Z","timestamp":1791929344276,"version":"4.3.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Introduction:&lt;\/i&gt; Left ventricular hypertrophy (LVH) is present in a majority of hemodialysis (HD) patients and is among the strongest risk factors for cardiovascular events and mortality. Hemofiltration (HF), a purely convective dialysis treatment, has been associated with enhanced hemodynamic stability compared with HD, possibly as a result of a more physiologic removal of fluid and solutes. &lt;i&gt;Methods:&lt;\/i&gt; In a randomized controlled study conducted at ten dialysis centers in Sweden and Denmark, incident patients (HD &lt;3 months) without clinical signs or history of cardiovascular disease were randomized to treatment with either online, predilution HF or low-flux HD. The primary endpoint was change in left ventricular mass index (LVMI), as measured by two-dimensional M-mode and Doppler echocardiography. &lt;i&gt;Results:&lt;\/i&gt; The analyses included 34 patients (18 HF, 16 HD) followed for up to 2 years. At baseline, 65% of the patients had LVH, but LVMI did not differ between the study groups. In the HF group, LVMI decreased by 22 \u00b1 48 g\/m&lt;sup&gt;2&lt;\/sup&gt; during a mean treatment time of 19 \u00b1 7 months, while in the HD group the decrease was 15 \u00b1 57 g\/m&lt;sup&gt;2&lt;\/sup&gt; during 16 \u00b1 7 months. As analyzed by MANOVA (mixed model), the difference in LVMI over the whole period was statistically significant (p = 0.03) with a more favorable outcome in HF. Blood pressure and other study variables did not differ between the groups, but at baseline and throughout the study, HF patients required heavier antihypertensive treatment. &lt;i&gt;Conclusions:&lt;\/i&gt; In incident dialysis patients, long-term predilution HF, a purely convective dialysis treatment, is associated with a significantly more favorable development of LVMI compared with regular low-flux HD. Considering the predictive strength of LVMI as a risk factor, the quantitative difference between the treatments is of clinical importance.<\/jats:p>","DOI":"10.1159\/000323140","type":"journal-article","created":{"date-parts":[[2011,1,21]],"date-time":"2011-01-21T07:44:46Z","timestamp":1295595886000},"page":"21-29","source":"Crossref","is-referenced-by-count":14,"title":["Left Ventricular Hypertrophy in Incident Dialysis Patients Randomized to Treatment with Hemofiltration or Hemodialysis: Results from the ProFil Study"],"prefix":"10.1159","volume":"32","author":[{"given":"Anders","family":"Alvestrand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Ledebo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger","family":"Hagerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Wingren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Mattsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Rashid","family":"Qureshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the ProFil Study Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1989.192"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2004.00530.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1998.00154.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F16.6.1207"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000170119"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2010030280"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2008.05.011"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9149%2886%2990771-X"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS1076-6332%2805%2980382-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1525-139X.2003.160271.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2005.12.029"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfh775"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000163845"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2002.00362.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2005040392"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.298.11.1291"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2005020132"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000104870"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.03340509"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323140","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:18:35Z","timestamp":1745435915000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000323140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,7,1]]},"published-print":{"date-parts":[[2011,7,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000323140","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}