{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:31:42Z","timestamp":1790688702285,"version":"4.1.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Pharmacol Physiol"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Ultraviolet B (UVB) radiation may cause an immediate inflammatory response followed by a delayed increase in skin pigmentation. The early time course of erythema and pigmentation has so far not been monitored simultaneously by photometric measurements. &lt;i&gt;Methods:&lt;\/i&gt; Test areas on the volar forearms of 15 volunteers were irradiated with 210 mJ\/cm&lt;sup&gt;2&lt;\/sup&gt; UVB. Skin erythema and pigmentation were determined photometrically at time 0, after 6 h, and after 1, 2, 3 and 7 days. Punch biopsies were taken before irradiation, after 6 h and after 7 days. Melanocytes were stained using the DOPA method. &lt;i&gt;Results:&lt;\/i&gt; UVB irradiation caused an increase in skin erythema at all time points, peaking at 24 h and slowly decreasing until day 7. Surprisingly, this was associated with a pronounced decrease in skin pigmentation at early readings. DOPA staining of melanocytes confirmed this observation. Only after 7 days was there an increase in skin pigmentation over the initial levels. &lt;i&gt;Conclusions:&lt;\/i&gt; Acute UVB-induced skin erythema seems to be associated with increased susceptibility to the deleterious effects of solar radiation due to a concomitant decrease in skin pigmentation. These findings underline the importance of avoiding even moderate sunburns and of slowly adapting the skin to solar radiation.<\/jats:p>","DOI":"10.1159\/000323274","type":"journal-article","created":{"date-parts":[[2011,1,12]],"date-time":"2011-01-12T08:58:23Z","timestamp":1294822703000},"page":"160-165","source":"Crossref","is-referenced-by-count":15,"title":["Double Trouble from Sunburn: UVB-Induced Erythema Is Associated with a Transient Decrease in Skin Pigmentation"],"prefix":"10.1159","volume":"24","author":[{"given":"F.","family":"Casetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Miese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.L.","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.M.","family":"Schempp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,1,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000065313"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0300-483X%2803%2900150-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.0022-202x.2001.01478.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.genet.37.110801.143233"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1751-1097.1996.tb02988.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12465094"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.124.6.869"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12456326"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1751-1097.1983.tb04533.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1751-1097.1986.tb04699.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0625.2003.00076.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0022-202X.2004.23464.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.141.12.1549"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0781.2006.00228.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0846.2007.00238.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1562%2F0031-8655%281999%29069%3C0341%3ASWBPTU%3E2.3.CO%3B2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0536.1996.tb02258.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000086669"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12581580"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0846.2000.006004230.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2009.09447.x"}],"container-title":["Skin Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:19:32Z","timestamp":1745435972000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000323274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,3,1]]},"published-print":{"date-parts":[[2011,3,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000323274","archive":["Portico"],"relation":{},"ISSN":["1660-5527","1660-5535"],"issn-type":[{"value":"1660-5527","type":"print"},{"value":"1660-5535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}