{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T07:35:21Z","timestamp":1746603321210,"version":"3.40.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Objective:<\/i> To evaluate the diagnostic value and compare morphological features of cell block sections of high-grade squamous intraepithelial lesions (HSIL) and squamous cell carcinomas (SCC). <i>Study Design:<\/i> A total of 135 cell blocks were prepared from residual Liqui-PREP samples. Of these, 43 biopsy-confirmed cases (24 HSIL and 19 SCC) were reviewed. Morphological features determined included cell clusters, epithelial-stromal interface, stromal invasion and tumor necrosis. <i>Results:<\/i> Ninety-three percent (40\/43) of cell block diagnoses were consistent with histological diagnoses, which was better than the cytological diagnoses (81.4%; 35\/43). The mean cell block size was 0.54 cm (range, 0.3\u20131.0 cm) for HSIL and 0.84 cm (range, 0.4\u20131.4 cm) for SCC (p < 0.0001). Cell clusters were present in 70.8% (17\/24) of HSIL and 100% (19\/19) of SCC (p < 0.0001). No epithelial-stromal interface, stromal invasion or tumor necrosis was observed on HSIL cell block sections, which is in contrast to the 84.2% (16\/19), 68.4% (13\/19) and 42.1% (8\/19) on SCC cell blocks, respectively (p < 0.05). <i>Conclusion:<\/i> Cell blocks may increase the diagnostic accuracy of liquid-based cytology. The presence of stromal invasion, epithelial-stromal interface and tumor necrosis on cell block sections may be useful for accurate SCC diagnosis.<\/jats:p>","DOI":"10.1159\/000323312","type":"journal-article","created":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T08:38:09Z","timestamp":1303893489000},"page":"245-250","source":"Crossref","is-referenced-by-count":4,"title":["Morphological Features of Cell Blocks Prepared from Residual Liqui-PREP Samples Can Distinguish between High-Grade Squamous Intraepithelial Lesions and Squamous Cell Carcinomas"],"prefix":"10.1159","volume":"55","author":[{"given":"Qingzhu","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianghuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,4,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2303.2006.00310.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fdc.10033"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fdc.10204"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.11102"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1309%2FG035-P2MM-D1TM-T5QE"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fdc.20634"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000325004"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0339%28200102%2924%3A2%3C142%3A%3AAID-DC1028%3E3.0.CO%3B2-G"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fdc.10173"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2820001025%2990%3A5%3C265%3A%3AAID-CNCR1%3E3.0.CO%3B2-Q"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0339%28199912%2921%3A6%3C427%3A%3AAID-DC12%3E3.0.CO%3B2-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncy.20061"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1177%2F002215540004800515"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fdc.10031"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.10716"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2FPAI.0b013e3181873c19"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2Fdc.20713"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2Fdc.20665"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2Fdc.10036"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2303.2009.00695.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2303.2007.00477.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002%2Fdc.20698"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323312","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:19:51Z","timestamp":1745435991000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000323312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,6,1]]},"published-print":{"date-parts":[[2011,4,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000323312","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"type":"print","value":"0001-5547"},{"type":"electronic","value":"1938-2650"}],"subject":[],"published":{"date-parts":[[2011]]}}}