{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:25:32Z","timestamp":1785407132619,"version":"3.56.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Objective:<\/i> To establish the efficacy and safety of once daily treatment of Daivobet\u00ae\/Dovobet\u00ae gel in patients with psoriasis vulgaris, relative to tacalcitol ointment and the gel vehicle alone. <i>Methods:<\/i> 458 patients with at least moderately severe disease were randomized in 3 treatment arms for an 8-week period. Treatment was investigator blinded, and treatment success was defined as patients with an Investigator\u2019s Global Assessment of \u2018clear\u2019 or \u2018almost clear\u2019 at week 8. <i>Results:<\/i> The proportion of patients who were \u2018clear or almost clear\u2019 was significantly higher in the 2-compound gel group (39.9%) compared with 17.9% in the tacalcitol group and 5.5% in the gel vehicle group: p < 0.001 in both comparisons. The proportion of patients with at least 1 adverse drug reaction was significantly lower in the 2-compound gel group compared to the other 2 treatment groups. <i>Conclusions:<\/i> Once-a-day treatment with the 2-compound Daivobet\/Dovobet gel is a safe and efficacious therapeutic regimen for individuals with psoriasis on the body.<\/jats:p>","DOI":"10.1159\/000323408","type":"journal-article","created":{"date-parts":[[2011,2,3]],"date-time":"2011-02-03T08:12:16Z","timestamp":1296720736000},"page":"148-156","source":"Crossref","is-referenced-by-count":44,"title":["Calcipotriol plus Betamethasone Dipropionate Gel Compared with Tacalcitol Ointment and the Gel Vehicle Alone in Patients with Psoriasis Vulgaris: A Randomized, Controlled Clinical Trial"],"prefix":"10.1159","volume":"222","author":[{"given":"Richard G.B.","family":"Langley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Papp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Wexler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Louise","family":"\u00d8sterdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du\u0161ica","family":"\u00c7ur\u010di\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,2,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.mpmed.2009.02.005"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature05663"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra0804595"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2807%2961128-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.143.12.1493"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4362.1993.tb05031.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080%2F13548500802512294"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2004.05986.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2004.05986.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2002.04967.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000066440"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2003.130"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080%2F00015550252948194"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clindermatol.2007.10.029"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2008.12.032"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080%2F09546630701646156"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2165%2F00128071-200405060-00012"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2006.07236.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159%2F000247698"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-3083.2006.01565.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323408","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:21:18Z","timestamp":1745436078000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000323408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,5,1]]},"published-print":{"date-parts":[[2011,5,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000323408","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}