{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T09:26:15Z","timestamp":1774085175921,"version":"3.50.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Neurosurg"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Background:<\/i> Atypical teratoid\/rhabdoid tumor (AT\/RT) is an aggressive malignant brain tumor that, since it was first identified, has been treated with aggressive treatment regimens, e.g. high-dose chemotherapy with stem cell rescue and early radiotherapy. We reviewed our experience because of concerns with respect to treatment-related toxicity in our patients. <i>Methods:<\/i> Seven patients with a median age at presentation of 18 months were diagnosed with AT\/RT between 1996 and 2006. Tumor location was supratentorial in 2 patients, in the posterior fossa in 4 and spinal in 1. Gross total resection was performed in 1 patient, subtotal resection in 5 and biopsy only in 1. Adjuvant treatment consisted of chemotherapy and radiotherapy in 5 patients. <i>Results:<\/i> Median progression-free survival was 4 months, and median overall survival was 7 months. Two children are alive at 44 and 102 months. Significant surgical and chemotherapy-related morbidity was seen. Biopsy-proven multifocal necrotizing leukoencephalopathy (MNL) was seen in one patient who is alive 44 months after diagnosis. Another patient who was thought to have recurrent tumor in the brainstem 9 months after diagnosis had imaging findings compatible with MNL. <i>Conclusion:<\/i> Although improving results are reported for AT\/RT using intensive treatment regimens, treatment-related morbidity is considerable in this young patient population.<\/jats:p>","DOI":"10.1159\/000323412","type":"journal-article","created":{"date-parts":[[2011,8,23]],"date-time":"2011-08-23T06:47:03Z","timestamp":1314082023000},"page":"7-14","source":"Crossref","is-referenced-by-count":12,"title":["Treatment-Related Morbidity in Atypical Teratoid\/Rhabdoid Tumor: Multifocal Necrotizing Leukoencephalopathy"],"prefix":"10.1159","volume":"47","author":[{"given":"A.","family":"Hasan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Palumbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.S.","family":"Carret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-P.","family":"Farmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Montes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Albrecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Saint-Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.R.","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00000478-199809000-00007"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00043426-200206000-00004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11060-005-6762-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.1996.85.1.0056"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11060-004-3115-y"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0899-7071%2899%2900165-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2008.18.7724"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fpbc.21578"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2004.07.073"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2005.05.187"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3171%2Ffoc.2005.18.6.9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2FMPH.0b013e3181b258a9"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097%2F00043426-199502000-00013"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fpbc.10419"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2F0046-8177%2893%2990140-C"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2990.1998.00099.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F00003246-200210000-00031"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%28197806%2941%3A6%3C2112%3A%3AAID-CNCR2820410607%3E3.0.CO%3B2-W"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%28197502%2935%3A2%3C291%3A%3AAID-CNCR2820350202%3E3.0.CO%3B2-V"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.63.7.1028"}],"container-title":["Pediatric Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:21:22Z","timestamp":1745436082000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000323412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,9,1]]},"published-print":{"date-parts":[[2011,9,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000323412","archive":["Portico"],"relation":{},"ISSN":["1016-2291","1423-0305"],"issn-type":[{"value":"1016-2291","type":"print"},{"value":"1423-0305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}