{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T12:44:32Z","timestamp":1753274672770,"version":"3.40.4"},"reference-count":25,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2011]]},"abstract":"Variants of t(8;21)(q22;q22) account for approximately 3% of all t(8;21) in acute myeloid leukemia (AML). We report a 63-year-old female patient with AML, who showed a 3-way novel variant of t(8;21), t(1;21;8)(q21;q22;q22). She presented with gastric discomfort and splenomegaly, and her complete blood count was: white blood cell count 7.96 \u00d7 10<sup>9<\/sup>\/l, with 7% blasts; hemoglobin 8.3 g\/dl, and platelets 66 \u00d7 10<sup>9<\/sup>\/l. Her bone marrow showed increased blasts (32.5%) with a basophilic cytoplasm, salmon-pink granules and Auer rods. Cytogenetic analysis revealed a karyotype of 46,XX,t(1;21;8)(q21;q22;q22), and fluorescence in situ hybridization confirmed a <i>RUNX1-RUNX1T1<\/i> fusion signal on the derivative chromosome 8. After induction chemotherapy, the patient achieved complete remission and has been stable for 6 months. To the best of our knowledge, this is the first report on the novel variant of t(8;21) involving the breakpoint 1q21 and the third case with a translocation among chromosomes 1, 21 and 8. Although the clinical relevance of variant t(8;21) is still unclear, a review of 24 such cases in the literature does not imply a poorer prognosis of variant t(8;21) than of the classic t(8;21).<\/jats:p>","DOI":"10.1159\/000323425","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T21:37:47Z","timestamp":1492551467000},"page":"237-241","source":"Crossref","is-referenced-by-count":7,"title":["Acute Myeloid Leukemia with a <i>RUNX1-RUNX1T1<\/i> t(1;21;8)(q21;q22;q22) Novel Variant: A Case Report and Review of the Literature"],"prefix":"10.1159","volume":"125","author":[{"given":"Hanah","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee-Won","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Hur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeo-Min","family":"Yun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark Hong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,2,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.critrevonc.2007.09.008"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.arcmed.2007.09.002"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0165-4608%2890%2990043-A"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cancergencyto.2004.11.006"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4103%2F0019-509X.40644"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs12185-007-0010-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-4608%2801%2900404-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cancergencyto.2007.10.005"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3109%2F10428190009054882"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0320%2820010201%2943%3A2%3C101%3A%3AAID-CYTO1024%3E3.0.CO%3B2-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cancergencyto.2008.10.004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS1525-1578%2810%2960479-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood.V98.5.1312"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.1997.2693088.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-4608%2897%2900033-2"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291098-2264%28199902%2924%3A2%3C165%3A%3AAID-GCC12%3E3.0.CO%3B2-1"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-4608%2898%2900121-6"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-4608%2899%2900185-5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3109%2F10428190109064613"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-4608%2801%2900550-7"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02982693"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cancergencyto.2004.03.016"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cancergencyto.2004.03.009"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cancergencyto.2008.03.008"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cancergencyto.2009.10.002"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323425","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323425","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:21:33Z","timestamp":1745436093000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000323425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,5,1]]},"published-print":{"date-parts":[[2011,5,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000323425","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2011]]}}}