{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:23:54Z","timestamp":1761863034298,"version":"3.40.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Specific immunotherapy with allergen is the only causative treatment for IgE-mediated allergies such as stinging insect allergy or hay fever and works by the induction of blocking antibodies and regulatory T lymphocytes. &lt;i&gt;Objective:&lt;\/i&gt; Does a hypothetical obstruction of tumor surveillance presupposing the induction of regulatory T cells really justify detaining immunotherapy to oncologic patients as suggested by recent guidelines? &lt;i&gt;Methods:&lt;\/i&gt; We report 6 patients (4 female, 2 male) suffering or having suffered from stage 1 cancer (4 melanomas, 1 lung cancer, 1 breast cancer) and concomitant IgE-mediated allergy. Four of them had a history of severe anaphylactic reactions to the insect yellow jacket, the 5th suffered from allergic rhinoconjunctivitis to dust mites, and the 6th to grass\/rye pollen. &lt;i&gt;Results:&lt;\/i&gt; Between 2004 and 2010, subcutaneous immunotherapy was safely performed in 5 patients without signs of tumor reactivation. The cancer in 2 of them was diagnosed immediately after specific immunotherapy had been initiated and in another 2 the active cancer phase had already finished years before; the 5th suffered from a relapse around the time of the initiation of immunotherapy. At the time of the writing of the manuscript, 4 of them had already concluded 3 years of treatment, another one almost 1 year. The melanoma in the 6th patient was diagnosed 5 months after reaching the maintenance dose. Immunotherapy with grass\/rye pollen was aborted in this patient based on current guidelines. &lt;i&gt;Conclusions:&lt;\/i&gt; Specific immunotherapy was safely administered in patients suffering concomitantly from IgE-mediated allergy and lower stage cancer.<\/jats:p>","DOI":"10.1159\/000323519","type":"journal-article","created":{"date-parts":[[2011,6,29]],"date-time":"2011-06-29T09:53:51Z","timestamp":1309341231000},"page":"313-319","source":"Crossref","is-referenced-by-count":17,"title":["Malignancy and Specific Allergen Immunotherapy: The Results of a Case Series"],"prefix":"10.1159","volume":"156","author":[{"given":"Stefan","family":"W\u00f6hrl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Kinaciyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Jalili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Stingl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina B.","family":"Moritz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,6,29]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1002%2Feji.200940045"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1016%2Fj.jaci.2007.06.013"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1016%2Fj.jaci.2006.11.010"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1002%2Fijc.22617"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1159%2F000103225"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1016%2FS0039-6109%2803%2900034-3"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1111%2Fj.1365-2362.2007.01807.x"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1378%2Fchest.08-0978"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1016%2Fj.ejca.2009.10.032"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1016%2Fj.jaci.2007.06.019"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1111%2Fj.1398-9995.2007.01620.x"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1016%2FS0091-6749%2897%2970188-X"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1016%2Fj.jaci.2009.08.027"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1067%2Fmai.2001.119154"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1111%2Fj.1398-9995.2008.01768.x"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1093%2Faje%2Fkwg020"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1093%2Faje%2Fkwi193"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1093%2Faje%2Fkwj065"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.1093%2Faje%2Fkwi241"},{"doi-asserted-by":"publisher","key":"ref20","DOI":"10.1002%2Fijc.21883"},{"doi-asserted-by":"publisher","key":"ref21","DOI":"10.1016%2Fj.imlet.2006.06.003"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323519","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:22:23Z","timestamp":1745436143000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000323519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,10,1]]},"published-print":{"date-parts":[[2011,10,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000323519","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2011]]}}}