{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:55:18Z","timestamp":1774439718524,"version":"3.50.1"},"reference-count":15,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Subcutaneous panniculitis-like T cell lymphoma (SPTL) is a rare subtype of non-Hodgkin lymphoma for which a definitive therapeutic strategy has not been established yet. We report a case of chemotherapy-resistant SPTL with hemophagocytic syndrome (HPS) which was successfully treated with cyclosporine A (CsA) plus methylprednisolone (mPSL), and also reviewed 11 SPTL cases treated with CsA, previously reported in the literature. Our patient was a 38-year-old female with SPTL. The disease progressed despite conventional chemotherapy using cytotoxic agents including alkylators, anthracyclins or purine analogues, and, after 2 months of chemotherapy, was eventually complicated by HPS and disseminated intravascular coagulation (DIC). CsA (4 mg\/kg\/day) plus mPSL treatment dramatically improved HPS with DIC, reduced subcutaneous tumors within 2 weeks, and finally induced complete remission (CR) after 3 months. Currently, the patient has maintained CR while being treated with CsA for 12 months. In addition to our case, 9 of 11 SPTL cases were successfully treated with CsA, and 8 were induced to CR. Time to first response to CsA was within 2 weeks in most cases, regardless of prior treatment or the co-occurrence of HPS. Our case and this first comprehensive review on CsA for SPTL suggest that CsA may constitute a candidate treatment strategy for SPTL.<\/jats:p>","DOI":"10.1159\/000323565","type":"journal-article","created":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T07:32:53Z","timestamp":1300347173000},"page":"8-12","source":"Crossref","is-referenced-by-count":34,"title":["Cyclosporine A for Chemotherapy-Resistant Subcutaneous Panniculitis-Like T Cell Lymphoma with Hemophagocytic Syndrome"],"prefix":"10.1159","volume":"126","author":[{"given":"Shinsuke","family":"Mizutani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Shimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Tsutsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihoko","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mio","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muneo","family":"Ohshiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Kiyota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuko","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoji","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Horiike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Taniwaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,3,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.20502"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2FMPH.0b013e31817588e8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2000.03671.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000226424"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2007-04-087288"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2803%2900746-1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1540-9740.2006.04689.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080%2F10428190601078456"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2169%2Finternalmedicine.45.1433"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2897%2980400-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.136.7.889"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.81.16.5214"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0162-3109%2800%2900192-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.2001.02844.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038%2Fnm1588"}],"container-title":["Acta 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