{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:39:22Z","timestamp":1770885562302,"version":"3.50.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Aims:<\/i> To investigate the levels of endothelin-1 (ET-1) and nitric oxide (NO) in the aqueous humor and plasma of human eyes with different types of glaucoma: primary open-angle glaucoma (POAG) and chronic closed-angle glaucoma (CCAG). <i>Methods:<\/i> Patients were classified into 3 groups: group I comprised 35 patients with POAG, group II comprised 25 patients with CCAG, and 30 patients with senile cataract (group III) were used as a control group. Aqueous humor and corresponding plasma were analyzed for ET-1 and NO concentrations by enzyme-linked immunosorbent assay. A Bonferroni correction for multiple comparisons was performed. <i>Results:<\/i> There was no significant difference in plasma levels of either ET-1 or NO metabolites between the groups studied. ET-1 and NO were significantly elevated in the aqueous humor of patients with CCAG and POAG compared to the corresponding value in patients with cataract (p < 0.001). ET-1 and NO concentrations in the aqueous humor were more marked in CCAG than in POAG. NO levels were correlated with ET-1 in the aqueous humor of patients with glaucoma (p < 0.001). <i>Conclusions:<\/i> Increased concentrations of ET-1 and NO in aqueous humor may be useful with POAG and CCAG. In addition, ET-1 and NO may have useful metabolite levels in the aqueous humor of POAG and CCAG patients as a result of glaucoma damage and may not be a cause of it.<\/jats:p>","DOI":"10.1159\/000323584","type":"journal-article","created":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T13:05:53Z","timestamp":1296479153000},"page":"98-102","source":"Crossref","is-referenced-by-count":45,"title":["Endothelin-1 and Nitric Oxide Levels in Patients with Glaucoma"],"prefix":"10.1159","volume":"46","author":[{"given":"Asaad A.","family":"Ghanem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M.","family":"Elewa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lmiaa F.","family":"Arafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clinbiochem.2005.11.001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3109%2F02713680903548970"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00061198-200206000-00016"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS1350-9462%2899%2900015-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3109%2F02713689209015075"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.2004.046755"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.03-0687"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2892%2990301-R"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2896%2991613-X"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000055508"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1006%2Fexer.1994.1199"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2F00061198-199802000-00012"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.96.17.9944"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0039-6257%2897%2984043-X"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2F0003-2697%2882%2990118-X"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F00061198-199704000-00003"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1755-3768.2007.01167.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00417-004-1097-2"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159%2F000066187"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1076%2Fceyr.26.2.119.14511"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323584","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323584","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:22:47Z","timestamp":1745436167000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000323584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,7,1]]},"published-print":{"date-parts":[[2011,7,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000323584","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}