{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:29:09Z","timestamp":1761290949082,"version":"3.40.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Surg"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Background:<\/i>Few data regarding survival or pattern of recurrence after laparoscopic liver resection (LLR) for hepatocellular carcinoma (HCC) on cirrhosis have been reported so far. <i>Methods:<\/i> A retrospective analysis of a prospectively maintained database of 109 laparoscopic interventional procedures performed for HCC in cirrhotic liver between 2000 and 2008 was conducted. <i>Results:<\/i> Sixty-five patients underwent an LLR. Morbidity rates were 20% (13\/65), whereas there was only 1 death (1.5%). Reoperation was required in 2 patients. The overall mean postoperative hospital stay was 8.2 (2.6; 3\u201315) days. The actuarial overall 1-, 3-, and 5-year survival rates were 95, 70, and 55%, respectively, with a median overall survival of 75 months. Excluding the one hospital death, the actuarial 1-, 3-, and 5-year disease-free survival rates were 81, 62, and 32%, respectively, with a median overall disease-free survival of 42 months (95% confidence interval, CI: 18\u201365). On multivariate analysis, tumor grade (OR: 3.5, 95% CI: 1.1\u201310.7, p = 0.026) and microvascular invasion (OR: 4.9, 95% CI: 1.2\u201318.8, p = 0.020) resulted as independent predictors of overall survival. On multivariate analysis, gender (OR: 3.4, 95% CI: 1.1\u201310.2, p = 0.023), satellite tumor (OR: 4.3, 95% CI: 1.5\u201312.3, p = 0.006), microvascular invasion (OR: 3.3, 95% CI: 1.0\u201310.1, p = 0.036) and surgical margin (OR: 3.7, 95% CI: 1.0\u201310.1, p = 0.036) were identified as independent prognostic predictors of better disease-free survival. After a median follow-up of 29 (range 3\u201381) months, 31 (48%) out of 64 patients had recurrence. The cumulative recurrence rates at 1, 3, and 5 years were 19, 39, and 68%, respectively. <i>Conclusion:<\/i> This prospective observational study has confirmed the feasibility and safety of LLR in selected patients with HCC in cirrhotic liver, and proved that it can warrant long-term outcome similar to those reported with the traditional open approach.<\/jats:p>","DOI":"10.1159\/000323824","type":"journal-article","created":{"date-parts":[[2011,4,29]],"date-time":"2011-04-29T06:49:46Z","timestamp":1304059786000},"page":"134-140","source":"Crossref","is-referenced-by-count":39,"title":["Laparoscopic Liver Resection for Hepatocellular Carcinoma in Cirrhosis: Long-Term Outcomes"],"prefix":"10.1159","volume":"28","author":[{"given":"Giulio","family":"Belli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Fantini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Belli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Limongelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,4,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F01.sla.0000206017.29651.99"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2FSLA.0b013e31816a747a"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053%2Fjlts.2002.34923"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00464-007-9487-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjsurg.2004.09.010"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00464-007-9503-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00534-005-1023-y"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11605-008-0537-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F01.sla.0000133083.54934.ae"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%28195405%297%3A3%3C462%3A%3AAID-CNCR2820070308%3E3.0.CO%3B2-E"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00534-009-0120-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jamcollsurg.2010.03.012"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097%2FSLA.0b013e3181bcaf46"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-199906000-00005"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-200107000-00011"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fbjs.6680"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-199503000-00012"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-199001000-00005"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2F0016-5085%2893%2990150-B"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-200004000-00014"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097%2F01.sla.0000231758.07868.71"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00268-006-0513-7"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-199001000-00005"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-199801000-00012"}],"container-title":["Digestive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323824","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:25:24Z","timestamp":1745436324000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000323824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,4,1]]},"published-print":{"date-parts":[[2011,4,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000323824","archive":["Portico"],"relation":{},"ISSN":["0253-4886","1421-9883"],"issn-type":[{"type":"print","value":"0253-4886"},{"type":"electronic","value":"1421-9883"}],"subject":[],"published":{"date-parts":[[2011]]}}}