{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T05:46:10Z","timestamp":1759988770905,"version":"3.40.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Background and Purpose:<\/i> This study was based on the hypothesis that suboptimal immune response and low serum immunoglobulin G (IgG) may predispose to age-related hearing loss (ARHL), and the objective was to determine the serum levels of IgG and hearing thresholds of apparently healthy elderly subjects and assess their correlation. <i>Method:<\/i> This prospective study involved 126 participants \u226760 years old who were found to be free of any medical conditions. Pure-tone averages for both the speech (500\u20132,000 Hz) and high frequencies (3,000\u20138,000 Hz) and serum IgG levels were determined. Using 30 dB as cut-off for hearing loss, the correlation with serum IgG was assessed. <i>Results:<\/i> There were 59 males and 67 females with a mean age \u00b1 SD of 67.0 \u00b1 2.7 years. Speech frequency hearing loss was seen in 30.2%, while high-frequency hearing loss accounted for 74.6%. In the speech frequencies, the mean \u00b1 SD of serum IgG among subjects with normal hearing was 11.3 \u00b1 3.9 g\/l, while among those with hearing loss it was 8.3 \u00b1 3.3 g\/l (p = 0.01). In the high frequencies, the mean \u00b1 SD values of serum IgG among the subjects with normal hearing was 11.1 \u00b1 2.3 g\/l, while among those with hearing loss it was 8.7 \u00b1 1.9 g\/l (p = 0.01). <i>Conclusion:<\/i> Low serum IgG may be a contributory factor to the development of ARHL among the elderly. However, a longitudinal study involving intervention with immunoglobulin supplementation may further confirm this role.<\/jats:p>","DOI":"10.1159\/000323830","type":"journal-article","created":{"date-parts":[[2011,2,8]],"date-time":"2011-02-08T08:42:25Z","timestamp":1297154545000},"page":"88-92","source":"Crossref","is-referenced-by-count":7,"title":["Correlation between Serum Immunoglobulin G and Hearing Threshold among Elderly Subjects with Age-Related Hearing Loss"],"prefix":"10.1159","volume":"73","author":[{"given":"Akeem Olawale","family":"Lasisi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatai A.","family":"Fehintola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oyindamola Bidemi","family":"Yusuf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oladapo O.","family":"Olayemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,2,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.90.17.7915"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0047-6374%2881%2990084-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0047-6374%2884%2990168-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0531-5565%2802%2900177-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bmt.1703152"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijporl.2005.08.009"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00405-007-0544-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Flt.20610"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080%2F00016480410016225"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1399-3046.2003.02054.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0531-5565%2896%2900070-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3109%2F10715769209049163"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038%2F468"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2F0378-5955%2894%2990052-3"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323830","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323830","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:25:27Z","timestamp":1745436327000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000323830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,3,1]]},"published-print":{"date-parts":[[2011,3,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000323830","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"type":"print","value":"0301-1569"},{"type":"electronic","value":"1423-0275"}],"subject":[],"published":{"date-parts":[[2011]]}}}