{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:42:22Z","timestamp":1782254542849,"version":"3.54.5"},"reference-count":15,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>The purpose of this study was to evaluate the expression of proinflammatory and immunoregulatory cytokines in chronic otitis media. The expression levels of TNF-\u03b1, IL-1\u03b1, IL-6 and IL-10 were determined by Western blot analysis of tissue samples obtained during ear surgery. The expression levels of TNF-\u03b1, IL-1\u03b1 and IL-6 in cholesteatoma tissues were substantially higher compared to those determined in the granulation tissue. The highest levels of TNF-\u03b1, IL-1 and IL-6 proteins were observed in patients with bone destruction. There were no significant differences in the expression of IL-10 levels in cholesteatoma and normal skin, but in the granulation tissue its level was substantially higher. The level of IL-10 in cholesteatoma tissues inversely correlated with the expression of proinflammatory cytokines, the degree of bone destruction and cholesteatoma invasion. Increased expressions of TNF-\u03b1, IL-1\u03b1 and IL-6 in chronic otitis media and a strong positive correlation between these cytokine levels and the degree of bone destruction indicate the destructive behavior of cholesteatoma or granulation tissue.<\/jats:p>","DOI":"10.1159\/000323831","type":"journal-article","created":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T07:57:26Z","timestamp":1297324646000},"page":"93-99","source":"Crossref","is-referenced-by-count":45,"title":["Expression of Tumor Necrosis Factor-\u03b1, Interleukin-1\u03b1, Interleukin-6 and Interleukin-10 in Chronic Otitis Media with Bone Osteolysis"],"prefix":"10.1159","volume":"73","author":[{"given":"Jerzy","family":"Kuczkowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Sakowicz-Burkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"I\u017cycka-\u015awieszewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogus\u0142aw","family":"Mikaszewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadeusz","family":"Pawe\u0142czyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,2,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.1997.tb51882.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3109%2F00016488409132918"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1017%2FS002221510013419X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0196-0709%2890%2990001-C"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10162-008-0153-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3109%2F00016489609137846"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F00129492-200209000-00007"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00005537-200007000-00025"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3342%2Fceo.2008.1.3.117"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F01.mlg.0000224345.59291.da"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00418-002-0460-9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1245%2Fs10434-009-0381-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1101%2Fsqb.1999.64.573"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0952-7915%2898%2980174-X"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F00005537-200209000-00024"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323831","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323831","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:25:27Z","timestamp":1745436327000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000323831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,3,1]]},"published-print":{"date-parts":[[2011,3,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000323831","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"value":"0301-1569","type":"print"},{"value":"1423-0275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}